Evidence map›Paper›PMID 39328058›Full record

ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2024

Patterns of soil-transmitted helminth aggregation in the human host population after several years of intensive mass drug administration.

Julia Mayer, Benjamin S Collyer, Rosie Maddren, Birhan Abtew, Ewnetu Firdawek Liyew, Melkie Chernet, Getachew Tollera, Geremew Tasew, Roy M Anderson

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In one paragraph

Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julia MayerDepartment of Infectious Disease Epidemiology, Imperial College London, School of Public Health Building, 90 Wood Lane, London W12 0BZ, UK.ORCID 0009-0005-0593-822X
Benjamin S CollyerDepartment of Infectious Disease Epidemiology, Imperial College London, School of Public Health Building, 90 Wood Lane, London W12 0BZ, UK.
Rosie MaddrenDepartment of Infectious Disease Epidemiology, Imperial College London, School of Public Health Building, 90 Wood Lane, London W12 0BZ, UK.ORCID 0000-0001-9363-3103
Birhan AbtewDepartment of Infectious Disease Epidemiology, Imperial College London, School of Public Health Building, 90 Wood Lane, London W12 0BZ, UK.
Ewnetu Firdawek LiyewBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Melkie ChernetBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Getachew TolleraBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Geremew TasewBacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
Roy M AndersonDepartment of Infectious Disease Epidemiology, Imperial College London, School of Public Health Building, 90 Wood Lane, London W12 0BZ, UK.

Funding

Children's Investment Fund Foundation R-1805-02741
6 · The paper itself

Abstract

backgroundCommunity-wide mass drug administration (cMDA) is known as an effective, albeit costly, control strategy for soil-transmitted helminth (STH) parasites. A better understanding of STH aggregation after many rounds of cMDA could help shape more cost-effective policies.

methodsThis analysis uses data from the Geshiyaro project, aiming to break STH transmission by cMDA and water, sanitation and hygiene interventions. Ascaris lumbricoides infection prevalence is derived from egg count data and parasite aggregation is obtained by fitting a negative binomial distribution to the frequency distribution of faecal egg counts.

resultsThe relationship between parasite dispersion and infection prevalence is approximately linear. Parasite aggregation increases as infection prevalence decreases.

conclusionsA minority of individuals carry most parasites as prevalence decreases in the community. These individuals could be selectively targeted for repeated treatment.

Indexed as

AnthelminticsAscariasisAscaris lumbricoidesFecesMass Drug AdministrationParasite Egg CountSoilAnimalsChildFemaleHelminthiasisHumansMalePrevalenceAnthelminticsSoilaggregationmass drug administrationsoil-transmitted helminths

Identifiers

PMID39328058
PMCPMC11638107

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.