Evidence map›Paper›PMID 39327935›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2024

Development of Low-Toxicity Antimicrobial Polycarbonates Bearing Lysine Residues.

Ruixuan Gao, Menglin Xue, Ning Shen, Xue Zhao, Justin C Zhang, Chuanhai Cao, Jianfeng Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruixuan GaoDepartment of Chemistry, University of South Florida, Tampa, FL 33620, United States.
Menglin XueDepartment of Chemistry, University of South Florida, Tampa, FL 33620, United States.
Ning ShenDepartment of Chemistry, University of South Florida, Tampa, FL 33620, United States.
Xue ZhaoDepartment of Chemistry, University of South Florida, Tampa, FL 33620, United States.
Justin C ZhangDepartment of Chemistry, University of South Florida, Tampa, FL 33620, United States.
Chuanhai CaoDepartment of Chemistry, University of South Florida, Tampa, FL 33620, United States.
Jianfeng CaiDepartment of Chemistry, University of South Florida, Tampa, FL 33620, United States.ORCID https://orcid.org/0000-0003-3106-3306

Funding

Novel polymer biomaterials combating C. difficile infectionR01AI149852 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG, SUN, XINGMIN · 2019 to 2023
$1.9M
Antimicrobial agents derived from AApeptide biomaterialsR01AI152416 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG · 2020 to 2024
$1.9M
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases R01AI149852, R01AI152416NIAID NIH HHS R01 AI149852NIAID NIH HHS R01 AI152416
6 · The paper itself

Abstract

Antibiotic resistance has been threatening public health for a long period, while the COVID pandemic aggravated the scenario. To combat antibiotic resistance strains, host defense peptides (HDPs) mimicking molecules have attracted considerable attention. Herein, we reported a series of polycarbonates bearing cationic lysine amino acid residues that could mimic the mechanism of action of HDPs and possess broad-spectrum antimicrobial activity. Moreover, those polymers had negligible toxicity toward red blood cells and mammalian cells. The membrane-disruption mechanism endows the lysine-containing polycarbonates with low possibility of resistance development and the fast killing kinetics, making them promising candidates for antimicrobial development.

Indexed as

LysinePolycarboxylate CementAnimalsAnti-Bacterial AgentsAnti-Infective AgentsErythrocytesHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAnti-Infective AgentsLysinepolycarbonatePolycarboxylate Cementantimicrobial agentshost-defense peptideslysine residuepolycarbonates

Identifiers

PMID39327935
PMCPMC11537833

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.