Evidence map›Paper›PMID 39327863›Full record

ReviewOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025

Managing Mandibular Osteoradionecrosis.

Michael A Fritz, Khashayar Arianpour, Sara W Liu, Eric D Lamarre, Dane J Genther, Peter J Ciolek, Patrick J Byrne, Brandon L Prendes

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  10. Osteoradionecrosis secondary to breast reirradiation.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael A FritzDivision of Facial Plastic and Microvascular Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Khashayar ArianpourDivision of Facial Plastic and Microvascular Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID http://orcid.org/0000-0002-4336-1776
Sara W LiuDivision of Facial Plastic and Microvascular Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Eric D LamarreDivision of Facial Plastic and Microvascular Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Dane J GentherDivision of Facial Plastic and Microvascular Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Peter J CiolekDivision of Facial Plastic and Microvascular Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Patrick J ByrneDivision of Facial Plastic and Microvascular Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Brandon L PrendesDivision of Facial Plastic and Microvascular Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMandibular osteoradionecrosis (MORN) is a morbid complication of head and neck radiation therapy. Recent advances in surgical and medical therapies underscore the need for a shift in traditional treatment paradigms and a disease grading system that can guide appropriate management. DATA SOURCES: Pubmed/MEDLINE. REVIEW

methodsWe conducted a detailed review of publications related to MORN, specifically focusing on its staging and management techniques. Articles meeting inclusion criteria were synthesized into a final narrative review.

conclusionThere has been a paradigm shift away from hyperbaric oxygen therapy in the management of MORN. Growing evidence for the efficacy of pentoxifylline and tocopherol in early-stage disease and novel surgical techniques to manage moderate and late-stage disease warrant an updated staging stratification which is proposed. IMPLICATIONS FOR PRACTICE: This review summarizes the clinical efficacy of established and novel therapeutic modalities currently available in treating MORN, emphasizing the significant advances achieved over the last decade. It introduces a contemporary staging and treatment algorithm which incorporates traditional, evidence-supported surgical and medical management with effective early intervention strategies.

Indexed as

Mandibular DiseasesOsteoradionecrosisHead and Neck NeoplasmsHumansHyperbaric OxygenationPentoxifyllinePentoxifyllinefree flaphead and neckjawmandiblemicrosurgeryosteoradionecrosisreconstructionrescue flapstaging

Identifiers

PMID39327863
PMCPMC11773448

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.