ArticleNature immunology2024
Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1
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Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
–field-weighted citation impact
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Who cites it
32 citing papers in PubMed.
- The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Targeting FAR1 to inhibit intestinal macrophage ferroptosis: repurposing irinotecan as a novel sepsis therapy.Apoptosis : an international journal on programmed cell death · 2026Article
- Targeting colorectal cancer and T‑cell metabolism for the treatment of colorectal cancer (Review).Oncology reports · 2026Review
- Targeting Pyruvate Kinase M2: Signal Transduction Pathways and Exploration of Cancer Therapeutic Strategies.The AAPS journal · 2026Review
- Targeting pyruvate kinase M2 (PKM2) reduces T cell pathogenicity in multiple sclerosis.EBioMedicine · 2026Article
- ASO-based PKM splice-switching therapy increases anti-CTLA-4 antibody efficacy in pancreatic ductal adenocarcinoma.Cell discovery · 2026Article
- CD8Cancer cell international · 2026Review
- Pentose phosphate pathway fuels cGAS-STING signalling to boost function of intratumoral conventional dendritic cells.Nature communications · 2026Article
- Review
- Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer.Signal transduction and targeted therapy · 2026Article
- Trained immunity in respiratory diseases: Mechanisms of action and intervention strategies.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Immunometabolic determinants of long-term response in leukemia patients receiving CD19 CAR T cell therapy.Nature communications · 2026Article
- Unveiling the inhibitory effects of tannic acid and doxorubicin combination on pyruvate kinase M2 in breast cancer cells.Frontiers in pharmacology · 2026Article
- Crosstalk between arachidonic acid metabolism and glycolysis drives integrated metabolic-inflammatory reprogramming in macrophages.International journal of biological sciences · 2026Article
- Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer.Oncology research · 2026Review
- The Role of Immune Checkpoint Inhibitors in Cancer Therapy: Mechanism and Therapeutic Advances.MedComm · 2025Review
- Review
- Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy.Molecular cancer · 2025Review
- Bi-directional metabolic reprogramming between cancer cells and T cells reshapes the anti-tumor immune response.PLoS biology · 2025Article
- PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti-TIGIT Therapy in Microsatellite-Stable Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Geoffrey J MarkowitzDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-3915-8078
Yi Ban *Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.
Diamile A Tavarez *Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.
Liron Yoffe *Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-3040-8205
Enrique Podaza *HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Yongfeng HeDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.
Mitchell T MartinDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.
Michael J P CrowleyDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.
Tito A SandovalSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2705-5282
Dingcheng GaoDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-3903-2603
M Laura MartinCaryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-9359-5856
Olivier ElementoHRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8061-9617
Juan R Cubillos-RuizWeill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-4267-4893
Timothy E McGrawDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-9748-263X
Nasser K AltorkiDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-9754-9945
Vivek MittalDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA. vim2010@med.cornell.edu.ORCID http://orcid.org/0000-0002-4764-7413
Funding
Institutional Career Development CoreKL2TR002385 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI YUAN-SHAN ZHU · 2017 to 2026
$13.3MMolecular and Translational Oncology ResearchT32CA203702 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLENIS, JOHN, GIANNAKAKOU, PARASKEVI · 2017 to 2021
$1.4MNCATS NIH HHS KL2 TR002385NCI NIH HHS T32 CA203702U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 5T32CA203702U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) KL2-TR-002385
Abstract
TCF1
Indexed as
CD8-Positive T-LymphocytesHepatocyte Nuclear Factor 1-alphaImmunotherapyPentose Phosphate PathwayThyroid Hormone-Binding ProteinsAnimalsGlycolysisHumansImmune Checkpoint InhibitorsMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutNeoplasmsProgrammed Cell Death 1 ReceptorPyruvate KinaseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseImmune Checkpoint InhibitorsMembrane ProteinsPkm protein, mouseProgrammed Cell Death 1 ReceptorPyruvate KinaseThyroid Hormone-Binding ProteinsThyroid Hormones
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.