Evidence map›Paper›PMID 39327441›Full record

ReviewNature reviews. Disease primers2024

Non-small-cell lung cancer.

Lizza E L Hendriks, Jordi Remon, Corinne Faivre-Finn, Marina C Garassino, John V Heymach, Keith M Kerr, Daniel S W Tan, Giulia Veronesi, Martin Reck

Erratum issued Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07303218 (The HER Project), which is not on this map. Cited by 358 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
358citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07303218 active not recruitingnot on this mapstarted 2025, after this paper: background citation

The HER Project: Homologous Recombination Deficiency in EGFR-Mutated NSCLC, a Retrospective and Prospective Translational Single-center Study

TypeobservationalSponsorIRCCS San RaffaeleRan2025 to 2032Enrolled100ConditionsEGFR, Non Small Cell Lung Cancer, Homologous Recombination Deficiency, PARP InhibitorArmsNo Intervention: Observational Cohort
3 · Its place in the literature

Who cites it

358 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  3. Clinical value of combinedOncology reviews · 2026
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  20. "What really works for us?" exploring therapeutic strategies for non-small cell lung cancer: an umbrella review of systematic reviews and meta-analyses.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review

298 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Lizza E L Hendriks *Department of Pulmonary Diseases, GROW-School for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0002-3521-2535
Jordi Remon *Department of Cancer Medicine, Gustave Roussy, Villejuif, France.
Corinne Faivre-FinnRadiotherapy Related Research, University of Manchester and The Christie NHS Foundation, Manchester, UK.
Marina C GarassinoThoracic Oncology Program, Section of Hematology Oncology, Department of Medicine, the University of Chicago, Chicago, IL, USA.
John V HeymachDepartment of Thoracic/Head and Neck Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-9068-8942
Keith M KerrDepartment of Pathology, Aberdeen Royal Infirmary and Aberdeen University Medical School, Aberdeen, UK.
Daniel S W TanNational Cancer Centre Singapore, Duke-NUS Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0002-6514-6786
Giulia VeronesiDepartment of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Martin ReckAirway Research Center North, German Center of Lung Research, Grosshansdorf, Germany. m.reck@lungenclinic.de.ORCID http://orcid.org/0000-0002-5348-4462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small-cell lung cancer (NSCLC) is one of the most frequent cancer types and is responsible for the majority of cancer-related deaths worldwide. The management of NSCLC has improved considerably, especially in the past 10 years. The systematic screening of populations at risk with low-dose CT, the implementation of novel surgical and radiotherapeutic techniques and a deeper biological understanding of NSCLC that has led to innovative systemic treatment options have improved the prognosis of patients with NSCLC. In non-metastatic NSCLC, the combination of various perioperative strategies and adjuvant immunotherapy in locally advanced disease seem to enhance cure rates. In metastatic NSCLC, the implementation of novel drugs might prolong disease control together with preserving quality of life. The further development of predictive clinical and genetic markers will be essential for the next steps in individualized treatment concepts.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsHumansImmunotherapyPrognosisQuality of Life

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.