Evidence map›Paper›PMID 39327412›Full record

SynthesisEuropean geriatric medicine2024

Comprehensive geriatric assessment, and related interventions, to improve outcomes for older patients undergoing transcatheter aortic valve implantation (TAVI): a systematic review.

Katherine Chin, Rosalind Jones, Eleni Lester, Alice Hegarty, Lieze Thielemans, Rebekah Schiff

Abstract readSystematic Review
In one paragraph

Synthesis in European geriatric medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katherine ChinDepartment of Ageing and Health, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Rosalind JonesDepartment of Ageing and Health, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Eleni LesterDepartment of Ageing and Health, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Alice HegartyDepartment of Ageing and Health, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Lieze ThielemansDepartment of Ageing and Health, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Rebekah SchiffDepartment of Ageing and Health, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK. rebekah.schiff@kcl.ac.uk.ORCID 0000-0001-6687-3726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTranscatheter aortic valve implantation (TAVI) is a treatment for people with severe symptomatic aortic stenosis, particularly those living with frailty. Increasing frailty is associated with poorer outcomes post-TAVI. Comprehensive Geriatric Assessment (CGA) has been shown in other settings to improve outcomes in those with frailty, including perioperatively. This systematic review aims to determine whether CGA, or interventions targeting its components, improves outcomes for older people undergoing TAVI.

methodsEMBASE, MEDLINE, CINAHL and Cochrane CENTRAL were searched on 09/01/23 and then the search was rerun on the 16/04/24. The review was registered on PROSPERO (CRD42022299955). Included studies had to evaluate either CGA, or a single- or multi-domain intervention targeting components of CGA, in those aged ≥ 65.

resultsFrom 4091 papers, 24 met the inclusion criteria. Two studies assessed CGA pre-TAVI and reported mixed improvements in functional independence but no change in length of stay or post-operative delirium, although both studies had a serious risk of bias. Fifteen papers described an exercise-based intervention, and 1 paper detailed a Cognitive Behavioural Therapy-based intervention. Seven studies evaluated a multi-component intervention. There were conflicting results reported for the multi-component and single-component interventions. All studies had at least a moderate risk of bias. CONCLUSION(S): There is a lack of evidence to determine whether CGA, or related interventions, improve outcomes for older adults undergoing-TAVI. The evidence for perioperative CGA, and the results of this review, support the need for well-designed trials evaluating whether CGA improves outcomes post-TAVI for older adults living with frailty.

Indexed as

Aortic Valve StenosisGeriatric AssessmentTranscatheter Aortic Valve ReplacementAgedAged, 80 and overFrail ElderlyFrailtyHumansPostoperative ComplicationsTreatment OutcomeCardiovascular diseaseComprehensive geriatric assessment (CGA)FrailtyOlder peopleTranscatheter aortic valve implantation (TAVI)

Identifiers

PMID39327412
PMCPMC11631815

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.