Evidence map›Paper›PMID 39327362›Full record

ArticleAnnals of surgical oncology2024

Reclassification of Appendiceal Mucinous Neoplasms and Associated Pseudomyxoma Peritonei According to the Peritoneal Surface Oncology Group International Consensus: Clinicopathological Reflections of a Two-Center Cohort Study.

Paulien Rauwerdink, Dania Al-Toma, Emma C E Wassenaar, Mihaela G Raicu, Miangela M Laclé, Anya N Milne, Karel C Kuijpers, Clément J R Huysentruyt, Floris B Poelmann, Bert van Ramshorst and 7 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Paulien RauwerdinkDepartment of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands. p.rauwerdink@antoniusziekenhuis.nl.
Dania Al-TomaDepartment of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
Emma C E WassenaarDepartment of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
Mihaela G RaicuDepartment of Pathology DNA, St. Antonius Hospital, Nieuwegein, The Netherlands.
Miangela M LacléDepartment of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Anya N MilneDepartment of Pathology DNA, St. Antonius Hospital, Nieuwegein, The Netherlands.
Karel C KuijpersDepartment of Pathology DNA, St. Antonius Hospital, Nieuwegein, The Netherlands.
Clément J R HuysentruytDepartment of Pathology, Catharina Cancer Institute - Eurofins PAMM, Eindhoven, The Netherlands.
Floris B PoelmannDepartment of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
Bert van RamshorstDepartment of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
Sjoerd G EliasJulius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Onno KranenburgLab Translational Oncology, Division Imaging and Cancer, University Medical Center Utrecht, Utrecht, The Netherlands.
Inne H M Borel RinkesLab Translational Oncology, Division Imaging and Cancer, University Medical Center Utrecht, Utrecht, The Netherlands.
Arjen J WitkampDepartment of Surgery, Division Imaging and Cancer, University Medical Centre Utrecht, Utrecht, The Netherlands.
Marinus J WiezerDepartment of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
Helma M U van GrevensteinDepartment of Surgery, Division Imaging and Cancer, University Medical Centre Utrecht, Utrecht, The Netherlands.
Djamila BoermaDepartment of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInternational consensus on classifications of appendiceal mucinous neoplasms (AMNs) and associated pseudomyxoma peritonei (PMP) have been carefully made but clinicopathological associations supporting decision making remain scarce.

objectiveThis study aimed to assess interdependence between AMNs and PMP and provide directions for clinical management.

methodsThis two-center retrospective cohort study reviewed patients with PMP treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy between 2005 and 2021. The primary objective was to reassess histopathologic grade of AMNs and PMP according to the Peritoneal Surface Oncology Group International classification and to establish its interdependence. Secondary outcomes were recurrence rate, PMP grade progression, ovarian involvement, and overall survival (OS).

resultsOf 105 patients included, 78 (74.3%) had low-grade AMNs as the primary tumor, 8 (7.6%) had high-grade AMNs, 7 (6.7%) had mucinous adenocarcinoma (MAC), 1 (0.9%) had MAC with signet ring cells (SRC), and 11 (10.5%) had unidentified tumors. Overall, 11 patients (10.5%) had no PMP, 21 (20.0%) had acellular mucin, 56 (53.3%) had low-grade PMP, 12 (11.4%) had high-grade PMP, and 5 (4.8%) had PMP-SRC. In 11 cases (13.3%), AMNs and matching PMP grade differed. Over a 16-year follow-up, recurrence occurred in 31.8%, with three cases showing histopathologically changed PMP. Ovarian involvement was observed in 43/65 females (66.2%). Median OS was 13.8 years, and 5-year OS rates were 100%, 74.4%, 44.4%, and 20% for acellular mucin, low-grade PMP, high-grade PMP and PMP-SRC, respectively (p < 0.001).

conclusionsAMN histology does not always reflects its associated PMP grade, while PMP grade strongly influences survival. Ovarian involvement and recurrent PMP showing unchanged histopathological features are common.

Indexed as

Adenocarcinoma, MucinousAppendiceal NeoplasmsCytoreduction Surgical ProceduresPeritoneal NeoplasmsPseudomyxoma PeritoneiAdultAgedCombined Modality TherapyConsensus Statements as TopicFemaleFollow-Up StudiesHumansHyperthermic Intraperitoneal ChemotherapyMaleMiddle AgedNeoplasm GradingAppendiceal mucinous neoplasmsCRS-HIPECLong-term prognosisOvarian involvementPseudomyxoma peritoneiPSOGI consensus classification

Identifiers

PMID39327362

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.