Evidence map›Paper›PMID 39327357›Full record

Observational studyJournal of nephrology2024

Association between cognitive functioning and health-related quality of life and its mediation by depressive symptoms in older patients with kidney failure.

Imre Demirhan, Mathijs van Oevelen, Zeinab Skalli, Carlijn G N Voorend, Simon P Mooijaart, Yvette Meuleman, Marianne C Verhaar, Willem Jan W Bos, Marjolijn van Buren, Alferso C Abrahams and 1 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Imre DemirhanDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands. i.demirhan-2@umcutrecht.nl.ORCID 0009-0000-7615-7176
Mathijs van OevelenDepartment of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.
Zeinab SkalliDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Carlijn G N VoorendDepartment of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.
Simon P MooijaartDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Yvette MeulemanDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Marianne C VerhaarDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Willem Jan W BosDepartment of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.
Marjolijn van Buren *Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.
Alferso C Abrahams *Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
DIALOGICA study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImpaired cognition, poor health-related quality of life (HRQoL) and depressive symptoms are common in older patients with kidney failure. Understanding what influences HRQoL is important, as older patients regard HRQoL as a health priority. This study examines whether cognitive functioning is associated with HRQoL and whether depressive symptoms mediate this effect in older patients with kidney failure.

methodsOutpatients aged ≥ 65 years from 35 Dutch and Belgian hospitals with eGFR 20-10 mL/min/1.73 m

resultsIn total, 403 patients were included, with a mean age of 76.5 years (SD 5.8) and estimated glomerular filtration rate (eGFR) of 14.5 mL/min/1.73 m

conclusionLower cognitive functioning was negatively associated with mental HRQoL, which was mediated by depressive symptoms in older patients with kidney failure. Future research should explore whether cognitive interventions and treatment of depression improve HRQoL in this vulnerable patient population.

Indexed as

CognitionDepressionGlomerular Filtration RateQuality of LifeAgedAged, 80 and overBelgiumCognitive DysfunctionCross-Sectional StudiesFemaleHumansMaleMediation AnalysisNetherlandsRenal InsufficiencyCognitive functioningKidney failureOlder patientsQuality of life

Identifiers

PMID39327357
PMCPMC11519205

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.