Evidence map›Paper›PMID 39327298›Full record

SynthesisArchives of gynecology and obstetrics2024

Association between pelvic inflammatory disease and risk of ovarian, uterine, cervical, and vaginal cancers-a meta-analysis.

Azharuddin Sajid Syed Khaja, Mohd Saleem, Mubashir Zafar, Soha Moursi, Ghorashy Eltayeb Yousif Mohammed, Syed Monowar Alam Shahid, Sahar Hammam, Safia Moussa, Mohammed Salem Alharbi, Ahmed Nawi Alshammari

Abstract readMeta-AnalysisSystematic Review
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In one paragraph

Synthesis in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Azharuddin Sajid Syed KhajaDepartment of Pathology, College of Medicine, University of Hail, 55476, Hail, Saudi Arabia. skazharuddin@uoh.edu.sa.ORCID 0000-0003-1594-1826
Mohd SaleemDepartment of Pathology, College of Medicine, University of Hail, 55476, Hail, Saudi Arabia.
Mubashir ZafarDepartment of Family and Community Medicine, College of Medicine, University of Hail, 55476, Hail, Saudi Arabia.
Soha MoursiDepartment of Pathology, College of Medicine, University of Hail, 55476, Hail, Saudi Arabia.
Ghorashy Eltayeb Yousif MohammedDepartment of Pathology, College of Medicine, University of Hail, 55476, Hail, Saudi Arabia.
Syed Monowar Alam ShahidDepartment of Biochemistry, College of Medicine, University of Hail, 55476, Hail, Saudi Arabia.
Sahar HammamDepartment of Microbiology, Maternity and Children Hospital, 55476, Hail, Saudi Arabia.
Safia MoussaDepartment of Microbiology, King Salman Specialist Hospital, 55476, Hail, Saudi Arabia.
Mohammed Salem AlharbiDepartment of Internal Medicine, College of Medicine, University of Hail, 55211, Hail, Saudi Arabia.
Ahmed Nawi AlshammariDepartment of Internal Medicine, College of Medicine, University of Hail, 55211, Hail, Saudi Arabia.

Funding

University of Hail RG-21 049
6 · The paper itself

Abstract

BACKGROUND AND

aimThe present meta-analysis aims to investigate a potential link between pelvic inflammatory disease (PID) and an increased risk of genitourinary cancers (ovarian, cervical, uterus, and vagina cancers). While previous research has hinted at a possible link, this meta-analysis seeks to delve deeper into the available evidence. Understanding this association is crucial for preventive strategies and improving clinical management practices. METHODOLOGY: A comprehensive literature search was conducted across various databases, covering studies published between 2016 and 2024. We included 13 observational studies meeting stringent criteria, followed by meticulous data extraction and quality assessment. Meta-analytical techniques were then employed to calculate pooled odds ratios (ORs), adjusted hazard ratios (HRs), and 95% confidence intervals (CIs), with heterogeneity assessed using the I

resultsOur analysis revealed significant findings, underscoring the association between PID and increased risks of genitourinary cancers. Specifically, individuals with a history of PID demonstrated notably higher odds of developing ovarian cancer (OR = 1.477, 95% CI 1.033-2.207), uterine cancer (OR = 1.263, 95% CI 0.827-2.143), cervical cancer (OR = 1.000, 95% CI 0.900-1.100), and vaginal cancer (OR = 2.500, 95% CI 1.400-4.000) compared to those without such a history. The overall heterogeneity across studies was high (I

conclusionThis meta-analysis provides updated evidence supporting a significant association between PID and an increased risk of cervical, ovarian, and uterine cancers. Early detection and management of PID are crucial in potentially mitigating the risk of these cancers.

Indexed as

Ovarian NeoplasmsPelvic Inflammatory DiseaseUterine NeoplasmsVaginal NeoplasmsFemaleHumansOdds RatioRisk FactorsEarly detectionGenitourinary cancersMeta-analysisPelvic inflammatory diseaseWomen’s health

Identifiers

PMID39327298

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.