Evidence map›Paper›PMID 39327269›Full record

ArticleJournal of neurology2024

Validation of the International REM Sleep Behavior Disorder Study Group Symptoms Severity Scale (IRBD-SSS): a new tool to assess RBD clinical severity.

Maria Livia Fantini, Ronald B Postuma, Monica Puligheddu, Isabelle Rieu, Enguerrand Venel, Michela Figorilli, Valerie Cochen-DeCock, Laurene Leclair-Visonneau, Dario Arnaldi, Pietro Mattioli and 9 more

Registry-linked trialAbstract readValidation StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04071899 (French Validation of a Severity Scale in REM Sleep Behavior Disorder), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04071899 unknown statusnot on this map

French Validation of a Severity Scale in REM Sleep Behavior Disorder

TypeobservationalSponsorUniversity Hospital, Clermont-FerrandRan2019 to 2020Enrolled80ConditionsREM Sleep Behavior DisorderArmsScale vaidation
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A gradual and sustainable approach to diagnosing sleep and circadian disturbances in dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Maria Livia FantiniSleep Disorders Center, Neurophysiology Unit, Neurology Department, Clermont-Ferrand University Hospital, Université Clermont Auvergne, CNRS, Institut Pascal, 58, Rue Montalembert, 63000, Clermont-Ferrand, France. maria_livia.fantini@uca.fr.ORCID http://orcid.org/0000-0002-0451-408X
Ronald B PostumaDepartment of Neurology, McGill University, Montreal Neurological Institute, Montreal, QC, Canada.
Monica PulighedduNeurology Unit, Department of Medical Sciences and Public Health, University of Cagliari and AOU, Cagliari, Italy.
Isabelle RieuSleep Disorders Center, Neurophysiology Unit, Neurology Department, Clermont-Ferrand University Hospital, Université Clermont Auvergne, CNRS, Institut Pascal, 58, Rue Montalembert, 63000, Clermont-Ferrand, France.
Enguerrand VenelSleep Disorders Center, Neurophysiology Unit, Neurology Department, Clermont-Ferrand University Hospital, Université Clermont Auvergne, CNRS, Institut Pascal, 58, Rue Montalembert, 63000, Clermont-Ferrand, France.
Michela FigorilliNeurology Unit, Department of Medical Sciences and Public Health, University of Cagliari and AOU, Cagliari, Italy.
Valerie Cochen-DeCockSleep and Neurology Department, Beau Soleil Clinic, Montpellier, France.
Laurene Leclair-VisonneauDepartment of Clinical Neurophysiology, CHU Nantes, Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, Nantes Université, Nantes, France.
Dario ArnaldiDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
Pietro MattioliDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
Laure Peter-DerexCenter for Sleep Medicine and Respiratory Diseases, Lyon University Hospital, Lyon 1 University, Lyon, France.
François RicordeauCenter for Sleep Medicine and Respiratory Diseases, Lyon University Hospital, Lyon 1 University, Lyon, France.
Michele TerzaghiUnit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy.
Isabelle ArnulfSleep Disorders Unit, Pitié-Salpêtrière University Hospital, AP-HP-Sorbonne, 75013, Paris, France.
Ambra StefaniDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Aleksandar VidenovicDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Coline ChirolSleep Disorders Center, Neurophysiology Unit, Neurology Department, Clermont-Ferrand University Hospital, Université Clermont Auvergne, CNRS, Institut Pascal, 58, Rue Montalembert, 63000, Clermont-Ferrand, France.
Bruno PereiraBiostatistics Unit, CHU University Hospital, Clermont-Ferrand, France.
International RBD Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, no standard scale has been validated to assess overall severity of RBD symptoms in the home environment. We aimed to evaluate the psychometric properties of the International RBD Severity Scale (IRBD-SSS), a new tool designed by the International RBD Study Group.

methodsTwo versions of the IRBD-SSS were created, one for the patient (IRBD-SSS-PT) and another for the bedpartner (IRBD-SSS-BP), both consisting of 3 components, namely vocalizations, body movements and injury, with a fourth component (patient version only) evaluating dream content. To score each dimension, the frequency and severity/impact of behaviors during the previous month are multiplied. Psychometric properties of the IRBD-SSS were assessed, including reproducibility.

resultsA total of 188 subjects including n = 132 RBD patients (n = 94 isolated RBD and n = 38 symptomatic RBD) and n = 52 bedpartners were enrolled from eight Sleep centers across France and Italy. Participants completed the scale at baseline and after one week. Acceptability of the scale was excellent in patients (97%) and bedpartners (98%). Internal consistency was acceptable for IRBD-SSS-PT (Cronbach α = 0.75) while slightly low for IRBD-SSS-BP (Cronbach α = 0.49). Concurrent validity was good for both patient (r = 0.70;p < 0.001, see Figure) and bedpartner (r = 0.69;p < 0.001) IRBD-SSS. Reproducibility was high for IRBD-SSS-PT (Lin's coefficient of agreement = 0.85 [0.81;0.90]) and good for the IRBD-SSS-BP (0.79 [0.68;0.90] (p < 0.001).

conclusionsBoth the patient and bedpartner versions of the IRBD-SSS showed excellent acceptability, acceptable internal consistency, good external validity and high reproducibility. IRBD-SSS is a useful tool to test the severity of RBD symptoms in clinical settings and clinical trials.

trial registrationNCT04071899.

Indexed as

PsychometricsREM Sleep Behavior DisorderSeverity of Illness IndexAgedFemaleHumansMaleMiddle AgedReproducibility of ResultsParasomniaREM sleep behavior disorderSeverity scale

Identifiers

PMID39327269

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.