Evidence map›Paper›PMID 39327057›Full record

Observational studyBMJ open2024

Combining electronic health records data from a clinical research network with registry data to examine long-term outcomes of interventions and devices: an observational cohort study.

Jialin Mao, Michael Matheny, Kim G Smolderen, Carlos Mena-Hurtado, Art Sedrakyan, Philip Goodney

Abstract readObservational Study
In one paragraph

Observational study in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jialin MaoPopulation Health Sciences, Joan and Sanford I Weill Medical College of Cornell University, New York, New York, USA jim2012@med.cornell.edu.ORCID 0000-0001-6671-3474
Michael MathenyDepartments of Biomedical Informatics, Biostatistics, and Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kim G SmolderenDepartment of Internal Medicine Section of Cardiovascular Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-6104-6254
Carlos Mena-HurtadoDepartment of Internal Medicine Section of Cardiovascular Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Art SedrakyanPopulation Health Sciences, Joan and Sanford I Weill Medical College of Cornell University, New York, New York, USA.
Philip GoodneyDepartment of Surgery Section of Vascular Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Incorporating Learning Effects into Medical Device Active Safety Surveillance MethodsR01HL149948 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATHENY, MICHAEL E., RESNIC, FREDERIC S · 2020 to 2023
$3.1M
Leveraging linked registry and electronic health records to examine long-term patient outcomes after peripheral vascular intervention"K01HL159315 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MAO, JIALIN · 2021 to 2025
$810k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K01 HL159315NHLBI NIH HHS R01 HL149948
6 · The paper itself

Abstract

objectivesTo assess the feasibility of assessing long-term outcomes of peripheral vascular intervention (PVI) by linking data from a clinical registry to electronic health records (EHR) data from a clinical research network.

designObservational cohort study.

settingVascular Quality Initiative registry linked to INSIGHT Clinical Research Network, which aggregated EHR data from multiple institutions in New York City.

participantsPatients receiving PVI during 1 January 2013-30 November 2021 in four centres in New York City. PRIMARY AND SECONDARY OUTCOME MEASURES: We examined the proportion of registry patients retained in EHR over time and predictors of EHR retention after year 1. We evaluated the implications of EHR attrition by examining amputation-free survival (AFS) in the observed data and predicted data when patients discontinued in the EHR were hypothesised to have increased risks of events than the observed average.

resultsWe included 1405 patients receiving PVI (age=70.8±11.2 years, 51.3% male). Among eligible patients, 75.2% were retained in EHR through year 3. Patients who aged 75 years or above (vs <65: OR 0.34, 95% CI 0.18 to 0.62), had Medicaid (vs Medicare: OR 0.41, 95% CI 0.22 to 0.79), congestive heart failure (OR 0.54, 95% CI 0.32 to 0.90), dialysis (OR 0.47, 95% CI 0.24 to 0.91) and reduced ambulation (OR 0.34, 95% CI 0.15 to 0.75) were less likely to be retained in EHR. When discontinued patients were hypothesised to have increased risks of death or amputation than observed, AFS estimates diverged from the observed data around 6-12 months.

conclusionsStudies using registry-EHR data may benefit from the timeliness of the data but may be most appropriate to focus on short-term to intermediate-term outcomes of interventions and devices. Future research is needed to investigate the value of registry-EHR linkage in facilitating short-term to intermediate-term outcome assessment following vascular interventions and advanced statistical approaches to account for non-random missing long-term data.

Indexed as

Electronic Health RecordsRegistriesAgedAged, 80 and overAmputation, SurgicalCohort StudiesFeasibility StudiesFemaleHumansMaleMiddle AgedNew York CityUnited StatesElectronic Health RecordsFollow-Up StudiesREGISTRIESVascular surgery

Identifiers

PMID39327057
PMCPMC11429269

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.