Evidence map›Paper›PMID 39326917›Full record

ArticleThe European respiratory journal2024

Airway tapering in COPD.

Sandeep Bodduluri, Arie Nakhmani, Abhilash S Kizhakke Puliyakote, Joseph M Reinhardt, Mark T Dransfield, Surya P Bhatt

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sandeep BodduluriCenter for Lung Analytics and Imaging Research, University of Alabama at Birmingham, Birmingham, AL, USA sbodduluri@uabmc.edu.
Arie NakhmaniCenter for Lung Analytics and Imaging Research, University of Alabama at Birmingham, Birmingham, AL, USA.
Abhilash S Kizhakke PuliyakoteDepartment of Radiology, University of Iowa Health Care, University of Iowa, Iowa City, IA, USA.
Joseph M ReinhardtRoy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
Mark T DransfieldDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Surya P BhattCenter for Lung Analytics and Imaging Research, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
1/2 Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease (Tele-COPD)UH3HL155806 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Surya P Bhatt · 2022 to 2026
$5.4M
Structural Determinants of Disease Progression in COPDR01HL151421 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P., NAKHMANI, ARIE · 2020 to 2024
$2.6M
Silent Zones of Lung Disease in COPDK01HL163249 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Sandeep Bodduluri · 2023 to 2026
$674k
Deep Learning and Fluid Dynamics Based Phenotyping of Expiratory Central Airway CollapseR21EB027891 · NIBIB · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P., RAGHAV, VRISHANK · 2019 to 2021
$599k
NHLBI NIH HHS K01 HL163249NHLBI NIH HHS R01 HL151421NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS UH3 HL155806NIBIB NIH HHS R21 EB027891
6 · The paper itself

Abstract

backgroundLuminal narrowing is a hallmark feature of airway remodelling in COPD, but current measures focus on airway wall remodelling. Quantification of the natural increase in cumulative cross-sectional area along the length of the human airway tree can facilitate assessment of airway narrowing.

methodsWe analysed the airway trees of 7641 subjects enrolled in the multicentre COPDGene cohort. Airway luminal tapering was assessed by estimating the slope of the change in cumulative cross-sectional area along the length of the airway tree over successive generations (T-Slope). We performed multivariable regression analyses to test the associations between T-Slope and lung function, St George's Respiratory Questionnaire score, modified Medical Research Council dyspnoea score, 6-min walk distance (6MWD), forced expiratory volume in 1 s (FEV

resultsThe mean±sd T-Slope decreased with increasing COPD severity: 2.69±0.70 mm

conclusionT-Slope is a measure of airway luminal remodelling and is associated with respiratory morbidity and mortality.

Indexed as

Airway RemodelingPulmonary Disease, Chronic ObstructiveTomography, X-Ray ComputedWalk TestAgedDisease ProgressionFemaleForced Expiratory VolumeHumansLungMaleMiddle AgedMultivariate AnalysisPulmonary EmphysemaRegression AnalysisSeverity of Illness Index

Identifiers

PMID39326917
PMCPMC11624106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.