Evidence map›Paper›PMID 39326883›Full record

ReviewAnnual review of virology2024

Are There More Human Cancer Viruses Left to Be Found?

Patrick S Moore, Yuan Chang

Abstract readReview
In one paragraph

Review in Annual review of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Patrick S MooreCancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; email: psm9@pitt.edu, yc70@pitt.edu.
Yuan ChangCancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; email: psm9@pitt.edu, yc70@pitt.edu.

Funding

Mechanism For Merkel Cell Polyomavirus PersistenceR01AI177607 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN CHANG · 2024 to 2026
$2.2M
Transcriptomic and Proteomic Approaches to Discovering Viral Causes for Human HemR01CA170354 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHANG, YUAN · 2012 to 2015
$1.3M
NCI NIH HHS R01 CA170354NIAID NIH HHS R01 AI177607
6 · The paper itself

Abstract

Of the thousands of viruses infecting humans, only seven cause cancer in the general population. Tumor sequencing is now a common cancer medicine procedure, and so it seems likely that more human cancer viruses already would have been found if they exist. Here, we review cancer characteristics that can inform a dedicated search for new cancer viruses, focusing on Kaposi sarcoma herpesvirus and Merkel cell polyomavirus as the most recent examples of successful genomic and transcriptomic searches. We emphasize the importance of epidemiology in determining which cancers to examine and describe approaches to virus discovery. Barriers to virus discovery, such as novel genomes and viral suppression of messenger RNA expression, may exist that prevent virus discovery using existing approaches. Optimally virus hunting should be performed in such a way that if no virus is found, the tumor can be reasonably excluded from having an infectious etiology and new information about the biology of the tumor can be found.

Indexed as

NeoplasmsOncogenic VirusesHerpesvirus 8, HumanHumansMerkel cell polyomavirusTumor Virus Infectionscancer virologyhuman tumor virusesKaposi sarcoma herpesvirusKSHVMCVMerkel cell polyomavirusvirus discovery

Identifiers

PMID39326883
PMCPMC12810255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.