Evidence map›Paper›PMID 39326869›Full record

ArticleJournal of the American Chemical Society2024

Cellular Prion Protein Conformational Shift after Liquid-Liquid Phase Separation Regulated by a Polymeric Antagonist and Mutations.

Yangyi Liu, Marcus D Tuttle, Mikhail A Kostylev, Graham P Roseman, Kurt W Zilm, Stephen M Strittmatter

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yangyi LiuDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, United States.
Marcus D TuttleDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, United States.ORCID 0009-0003-0640-2385
Mikhail A KostylevDepartments of Neuroscience and Neurology, Yale School of Medicine, 100 College Street, New Haven, Connecticut 06510, United States.
Graham P RosemanDepartments of Neuroscience and Neurology, Yale School of Medicine, 100 College Street, New Haven, Connecticut 06510, United States.
Kurt W ZilmDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, United States.
Stephen M StrittmatterDepartments of Neuroscience and Neurology, Yale School of Medicine, 100 College Street, New Haven, Connecticut 06510, United States.ORCID 0000-0001-8188-3092

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2M
Prion Protein in Alzheimer's Disease PathophysiologyR01AG034924 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2010 to 2026
$9.6M
Structural Mechanism of Mammalian Prion InfectivityR01NS118796 · NINDS · DARTMOUTH COLLEGE · PI SUPATTAPONE, SURACHAI, ZILM, KURT WILLIAM · 2020 to 2024
$2.8M
Synaptic selectivity for microglial-mediated damage in Alzheimer's DiseaseR01AG070926 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2024 to 2025
$1.6M
NCATS NIH HHS UL1 TR001863NIA NIH HHS P30 AG066508NIA NIH HHS R01 AG034924NIA NIH HHS R01 AG070926NINDS NIH HHS R01 NS118796
6 · The paper itself

Abstract

Liquid-liquid phase separation (LLPS) of intrinsically disordered proteins has been associated with neurodegenerative diseases, although direct mechanisms are poorly defined. Here, we report on a maturation process for the cellular prion protein (PrP

Indexed as

MutationHumansMaleatesPhase SeparationPrion ProteinsProtein ConformationPrPC ProteinsSulfonic AcidsMaleatesmaleic acidPrion ProteinsPrPC ProteinsSulfonic Acids

Identifiers

PMID39326869
PMCPMC11469297

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.