ArticleScience (New York, N.Y.)2024
A kalihinol analog disrupts apicoplast function and vesicular trafficking in
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Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
–field-weighted citation impact
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Who cites it
7 citing papers in PubMed.
- Paclitaxel-induced tubulin dysfunction stalls parasite development: synergistic potential with artemisinin against resistant strains.Microbiology spectrum · 2026Article
- Genome-Guided Discovery of Antimalarial 4-Amino-2,4-Pentadienoate-Containing Cyclolipodepsipeptides.Angewandte Chemie (International ed. in English) · 2026Article
- Polypharmacology in malaria treatment: single drugs, multiple mechanisms, greater impact.Trends in parasitology · 2026Review
- The Enigma of Sponge-Derived Terpenoid Isothiocyanate-Thiocyanate Pairs: A Biosynthetic Proposal.Marine drugs · 2025Review
- The Paradox of Antimalarial Terpenoid Isonitrile Biosynthesis Explained. Proposal of Cyanoformate as an NC Delivery Vector.Journal of natural products · 2025Article
- Practical implementation and impact of the 4R principles in ethnopharmacology: Pursuing a more humane approach to research.Frontiers in pharmacology · 2025Review
- A Divergent Synthesis of Numerous Pyrroloiminoquinone Alkaloids Identifies Promising Antiprotozoal Agents.Journal of the American Chemical Society · 2024Article
Corrections and comments
- Update of
Authors and funding
29 authors.
Z ChahineDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.ORCID 0000-0001-8208-5869
S AbelDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
T HollinDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.ORCID 0000-0002-8089-3253
G L BarnesDepartment of Chemistry, University of California, Irvine, CA, USA.ORCID 0000-0002-5731-4380
J H ChungDepartment of Chemistry, University of California, Irvine, CA, USA.ORCID 0000-0001-8665-9348
M E DaubDepartment of Chemistry, University of California, Irvine, CA, USA.ORCID 0000-0002-1368-9607
I RenardDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4121-143X
J Y ChoiDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-9853-0987
P VydyamDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4944-6006
A PalDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0068-8912
M Alba-ArgomanizDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.ORCID 0009-0008-0505-9390
C A S BanksStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0002-0404-2940
J KirkwoodMetabolomics Core Facility, University of California, Riverside, CA, USA.ORCID 0000-0002-5679-3500
A SarafStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0001-6756-0975
I CaminoGSK, Tres Cantos (Madrid), Spain.ORCID 0009-0005-4024-6894
P CastanedaGSK, Tres Cantos (Madrid), Spain.ORCID 0000-0002-0514-7306
M C CuevasGSK, Tres Cantos (Madrid), Spain.
J De Mercado-ArnanzGSK, Tres Cantos (Madrid), Spain.ORCID 0000-0002-6140-2340
E Fernandez-AlvaroGSK, Tres Cantos (Madrid), Spain.ORCID 0000-0001-9287-5012
A Garcia-PerezGSK, Tres Cantos (Madrid), Spain.ORCID 0009-0008-3709-043X
N IbarzGSK, Tres Cantos (Madrid), Spain.ORCID 0009-0008-3392-4812
S Viera-MorillaGSK, Tres Cantos (Madrid), Spain.ORCID 0000-0002-2025-4804
J PrudhommeDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.ORCID 0000-0002-6161-5194
C J JoynerDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.ORCID 0000-0003-1367-2829
A K BeiDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0003-1159-760X
L FlorensStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0002-9310-6650
C Ben MamounDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5028-1400
C D VanderwalDepartment of Chemistry, University of California, Irvine, CA, USA.ORCID 0000-0001-7218-4521
K G Le RochDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.ORCID 0000-0002-4862-9292
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MFosinopril analogs for the treatment of human babesiosisR01AI153100 · NIAID · YALE UNIVERSITY · PI BEN MAMOUN, CHOUKRI · 2021 to 2025
$3.6MHit-to-Lead Development of the Kalihinol Scaffold for Malaria TreatmentR01AI138139 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BEN MAMOUN, CHOUKRI, LE ROCH, KARINE GAELLE · 2018 to 2022
$3.6MChromatin structure and control of gene expression in the human malaria parasiteR01AI136511 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2018 to 2022
$3.4MRAPs-mediated post-transcriptional control in Apicomplexan parasitesR01AI142743 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2018 to 2022
$2.8MDevelopment of endochin-like quinolones for babesiosis therapyR01AI123321 · NIAID · YALE UNIVERSITY · PI BEN MAMOUN, CHOUKRI · 2017 to 2020
$2.7MAntigen Discovery and Vaccine Development for Human Babesia ParasitesR01AI152220 · NIAID · YALE UNIVERSITY · PI BEN MAMOUN, CHOUKRI · 2020 to 2024
$2.1MAn antigen-detection assay to diagnose Babesia microti infectionR44AI136118 · NIAID · L2 DIAGNOSTICS, LLC · PI LEDIZET, MICHEL · 2020 to 2022
$2.1MEmploying genetic and genomic surveillance to reveal mechanisms of malaria parasite persistenceK01TW010496 · FIC · YALE UNIVERSITY · PI BEI, AMY KRISTINE · 2016 to 2021
$754kIllumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600kAn antigen-detection assay to diagnose Babesia microti infectionR43AI136118 · NIAID · L2 DIAGNOSTICS, LLC · PI LEDIZET, MICHEL · 2018 to 2018
$300kFIC NIH HHS K01 TW010496Gates Foundation INV-031788NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI123321NIAID NIH HHS R01 AI136511NIAID NIH HHS R01 AI138139NIAID NIH HHS R01 AI142743NIAID NIH HHS R01 AI152220NIAID NIH HHS R01 AI153100NIAID NIH HHS R43 AI136118NIAID NIH HHS R44 AI136118NIH HHS P51 OD011132NIH HHS S10 OD026929
Abstract
We report the discovery of MED6-189, an analog of the kalihinol family of isocyanoterpene natural products that is effective against drug-sensitive and drug-resistant
Indexed as
AntimalarialsApicoplastsDiterpenesMalaria, FalciparumPlasmodium falciparumAnimalsDisease Models, AnimalDrug ResistanceHumansMiceMutationProtozoan ProteinsAntimalarialsDiterpenesProtozoan Proteins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.