Evidence map›Paper›PMID 39325787›Full record

Observational studyPloS one2024

Impact of sinus surgery in people with cystic fibrosis and chronic rhinosinusitis in the era of highly effective modulator therapy: Protocol for a prospective observational study.

Christine M Liu, Jakob L Fischer, Jeremiah A Alt, Todd E Bodner, Naweed I Chowdhury, Anne E Getz, Peter H Hwang, Adam J Kimple, Jess C Mace, Timothy L Smith and 5 more

Registry-linked trialAbstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04469439 (The Impact of Sinus Surgery in the Era of Highly Effective Modulatory Therapy), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04469439 recruitingnot on this map

The Impact of Sinus Surgery in the Era of Highly Effective Modulatory Therapy

TypeobservationalSponsorUniversity of California, Los AngelesRan2020 to 2027Enrolled170ConditionsChronic Rhinosinusitis (Diagnosis), Cystic Fibrosis
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Christine M LiuDepartment of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, Los Angeles, CA, United States of America.ORCID 0000-0001-9985-4775
Jakob L FischerDepartment of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, Los Angeles, CA, United States of America.ORCID 0000-0002-8896-671X
Jeremiah A AltDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, UT, United States of America.
Todd E BodnerDepartment of Psychology, Portland State University, Portland, OR, United States of America.
Naweed I ChowdhuryDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt Health, Nashville, TN, United States of America.
Anne E GetzDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado, Boulder, CO, United States of America.
Peter H HwangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, United States of America.
Adam J KimpleDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, NC, United States of America.ORCID 0000-0003-1670-8401
Jess C MaceDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, OR, United States of America.
Timothy L SmithDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, OR, United States of America.
Zachary M SolerDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, United States of America.
Christopher H GossDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, United States of America.
Jennifer L Taylor-CousarDepartment of Medicine, National Jewish Health, Denver, CO, United States of America.
Milene T SaavedraDepartment of Medicine, National Jewish Health, Denver, CO, United States of America.
Daniel M BeswickDepartment of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, Los Angeles, CA, United States of America.ORCID 0000-0001-8612-5442

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
Enabling careers as surgeon-scientists in otolaryngology-head and neck surgeryR25DC020151 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jennifer L Long · 2022 to 2026
$887k
NIDCD NIH HHS R25 DC020151NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

introductionCystic fibrosis (CF) is commonly complicated by chronic rhinosinusitis (CRS). Despite highly effective management options, CRS in people with CF (PwCF+CRS) may be refractory to medical therapy, eventually requiring endoscopic sinus surgery. The impact of sinus surgery on pulmonary, quality of life (QOL), and other outcomes in PwCF+CRS in the expanding era of highly effective modulator therapy has not been fully elucidated. This study aims to determine if endoscopic sinus surgery can offer superior outcomes for PwCF+CRS when compared to continued medical treatment of CRS. METHODS AND ANALYSIS: This multi-institutional, observational, prospective cohort study will enroll 150 adults with PwCF+CRS across nine US CF Centers who failed initial medical therapy for CRS and elected to pursue either endoscopic sinus surgery or continue medical treatment. To determine if sinus surgery outperforms continued medical therapy in different outcomes, we will assess changes in pulmonary, CF-specific QOL, CRS-specific QOL, sleep quality, depression, headache, cognition, olfaction, productivity loss, and health utility value after treatment. The influence of highly effective modulator therapy on these outcomes will also be evaluated. This study will provide crucial insights into the impact of endoscopic sinus surgery for PwCF+CRS and aid with development of future treatment pathways and guidelines. ETHICS AND DISSEMINATION: This study has been approved by each institution's internal review board, and study enrollment began August 2019. Results will be disseminated in conferences and peer-reviewed journals.

trial registrationThis study was registered on ClinicalTrials.gov (NCT04469439).

Indexed as

Cystic FibrosisQuality of LifeRhinitisSinusitisAdultChronic DiseaseEndoscopyFemaleHumansMaleObservational Studies as TopicParanasal SinusesProspective StudiesRhinosinusitisTreatment Outcome

Identifiers

PMID39325787
PMCPMC11426423

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.