ArticleAmerican journal of hypertension2024
Blood Pressure Trajectories During Young Adulthood and Cardiovascular Events in Later Life.
Article in American journal of hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- SREBP gene polymorphisms and ambulatory blood pressure parameters in Chinese adolescents: a cross-sectional study.European journal of pediatrics · 2026Article
- Hypertension Among Medical Students in Lubumbashi, Democratic Republic of the Congo: Prevalence, Associated Factors and Comparison of the 2025 ACC/AHA and JNC 7 Classifications.International journal of hypertension · 2026Article
- Delayed Treatment, Lasting Consequences: The Need for Early Hypertension Diagnosis and Management in Young Adults.American journal of hypertension · 2025Article
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6 authors.
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Abstract
backgroundStudying the association between blood pressure (BP) trajectories during young adulthood and subsequent cardiovascular disease (CVD) risk can provide insights into how long-term BP patterns in early-life influence the development of CVD later in life.
methodsWe pooled data from 2 US cohorts (Coronary Artery Risk Development in Young Adults, Framingham Heart Study). We used latent growth curve models to identify distinct BP trajectory groups between ages 18 and 39 years. We then used Cox proportional hazards models to assess the associations between BP trajectories and CVD events (composite of coronary heart disease [CHD], stroke, and heart failure [HF]) after age 40 years.
resultsWe included 6,579 participants and identified 4 distinct systolic BP (SBP) trajectory groups during young adulthood. During a median follow-up of 18.2 years after age 40 years, 213 CHD, 139 stroke, 120 HF, and 400 composite CVD events occurred. Individuals in an elevated-increasing vs. low-stable SBP trajectory during young adulthood were associated with a higher risk of CVD after adjusting for traditional CVD risk factors, with hazard ratios (95% confidence interval) of 3.25 (1.63, 6.46) for CHD, 3.92 (1.63, 9.43) for stroke, 8.30 (2.97, 23.17) for HF, and 3.91 (2.38, 6.41) for composite CVD outcomes. Adding BP trajectory to BP at baseline improved model discrimination for all outcomes (changes in Harrell's C-index 0.0084-0.0192).
conclusionsAn elevated-increasing BP trajectory during young adulthood is associated with a higher risk of CVD later in life, highlighting the importance of maintaining a low-stable BP trajectory throughout the young adulthood period for prevention of CVD in later life.
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