Evidence map›Paper›PMID 39325622›Full record

ArticleCell reports2024

Placenta-derived SOD3 deletion impairs maternal behavior via alterations in FGF/FGFR-prolactin signaling axis.

Yidan Xu, Ana B Alves-Wagner, Hitoshi Inada, Sepideh D Firouzjah, Shion Osana, Muhammad Subhan Amir, Royce H Conlin, Michael F Hirshman, Eva S Nozik, Laurie J Goodyear and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yidan XuDepartment of Biosignals and Inheritance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan; Department of Medicine and Science in Sports and Exercise, Tohoku University School of Medicine, Sendai 980-8575, Japan.
Ana B Alves-WagnerSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Hitoshi InadaDepartment of Medicine and Science in Sports and Exercise, Tohoku University School of Medicine, Sendai 980-8575, Japan; Department of Developmental Neuroscience, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Sepideh D FirouzjahDepartment of Biosignals and Inheritance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan.
Shion OsanaDepartment of Medicine and Science in Sports and Exercise, Tohoku University School of Medicine, Sendai 980-8575, Japan; Division of Biomedical Engineering for Health and Welfare, Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8575, Japan.
Muhammad Subhan AmirDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Airlangga University, Surabaya 60132, Indonesia; Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai 980-8578, Japan.
Royce H ConlinSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Michael F HirshmanSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Eva S NozikCardiovascular Pulmonary Research Laboratories and Pediatric Critical Care, Department of Pediatrics, the University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA.
Laurie J GoodyearSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Ryoichi NagatomiDepartment of Medicine and Science in Sports and Exercise, Tohoku University School of Medicine, Sendai 980-8575, Japan; Department of Developmental Neuroscience, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Joji KusuyamaDepartment of Biosignals and Inheritance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan; Department of Medicine and Science in Sports and Exercise, Tohoku University School of Medicine, Sendai 980-8575, Japan; Division of Biomedical Engineering for Health and Welfare, Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8575, Japan; Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai 980-8578, Japan. Electronic address: joji.kusuyama.bsin@tmd.ac.jp.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Exercise Regulation of Glucose Homeostasis Administrative SupplementR01DK101043 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 2013 to 2026
$7.3M
SOD3 regulation of redox sensitive signaling in pulmonary vascular diseasesR35HL139726 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI NOZIK, EVA S. · 2018 to 2024
$4.1M
NHLBI NIH HHS R35 HL139726NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK101043
6 · The paper itself

Abstract

Offspring growth requires establishing maternal behavior associated with the maternal endocrine profile. Placentae support the adaptations of the mother, producing bioactive molecules that affect maternal organs. We recently reported that placentae produce superoxide dismutase 3 (SOD3) that exerts sustained effects on the offspring liver via epigenetic modifications. Here, we demonstrate that placenta-specific Sod3 knockout (Sod3

Indexed as

Fibroblast Growth FactorsPlacentaProlactinSignal TransductionSuperoxide DismutaseAnimalsFemaleGene DeletionMaternal BehaviorMiceMice, Inbred C57BLMice, KnockoutPituitary GlandPregnancyReceptor, Fibroblast Growth Factor, Type 2Fibroblast Growth FactorsProlactinReceptor, Fibroblast Growth Factor, Type 2Superoxide DismutaseCP: Cell biologyCP: Developmental biologyDNA demethylationexercisegrandoffspringmaternal exercisenurturingpituitary glandplacentaplacentokinepregnancy

Identifiers

PMID39325622
PMCPMC11639441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.