Evidence map›Paper›PMID 39325364›Full record

ArticleCell biochemistry and biophysics2025

The Novel Nephroprotective Activity of Flaxseed Oil on Diazinon-induced Kidney Damage in Male Rats.

Narges Farokhi, Akram Ranjbar, Fereshteh Mehri, Mahdi Ramezani

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Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Narges FarokhiDepartment of Pharmacology and Toxicology, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Akram RanjbarDepartment of Pharmacology and Toxicology, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Fereshteh MehriNutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Hamadan, Iran. freshteh_mehri@yahoo.com.
Mahdi RamezaniNeurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In male rats, the flaxseed oil (FS-oil) modulatory properties were investigated on diazinon (DZN)-induced nephrotoxicity. Adult male Wistar rats were divided randomly into five groups. To induce nephrotoxicity, animals received DZN (70 mg/kg/day, p.o.). Also, treatment groups received FS-oil (100 and 200 mg/kg/day, p.o.). The animal treatment was 28 consecutive days. On the 29th day, serum and kidney tissue samples were removed and serum levels of the creatinine, blood urea nitrogen (BUN), malondialdehyde (MDA), glutathione peroxidase (GPx), and catalase (CAT), were measured. Also, hematoxylin and eosin (H&E) staining was applied for histological studies. DZN significantly increased the BUN, creatinine, and MDA levels compared to the control group. Besides, DZN significantly decreased the GPx and CAT activity in the kidney tissue. However, the modulatory effects of FS-oil were observed by improving renal enzyme factors, inhibiting oxidative stress, and histological change. This study demonstrated that FS-oil ameliorated DZN-induced nephrotoxicity and can be used as a preventive agent against DZN toxicity because of the FS-oil antioxidant characteristics.

Indexed as

DiazinonKidneyKidney DiseasesLinseed OilProtective AgentsAnimalsAntioxidantsBlood Urea NitrogenCatalaseCreatinineGlutathione PeroxidaseMaleMalondialdehydeOxidative StressRatsRats, WistarAntioxidantsCatalaseCreatinineDiazinonGlutathione PeroxidaseLinseed OilMalondialdehydeProtective AgentsBlood urea nitrogenDiazinonFlaxseed oilNephrotoxicity

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PMID39325364

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