Molecular Dissection of the Arsenic-Induced Leukocyte Incursion into the Inflamed Thymus and Spleen and Its Amelioration by Co-supplementation of L-Ascorbic Acid and α-Tocopherol.

Jeet Maity, Priyankar Pal, Madhurima Ghosh, Bhagyashree Naskar, Santanu Chakraborty, Ranjana Pal, Prabir Kumar Mukhopadhyay

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Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Jeet MaityDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.

Priyankar PalDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.

Madhurima GhoshDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.

Bhagyashree NaskarDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.

Santanu ChakrabortyDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.

Ranjana PalDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.

Prabir Kumar MukhopadhyayDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India. prabir.dbs@presiuniv.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arsenic, a surreptitious presence in our environment, perpetuates a persistent global menace with its deleterious impacts. It possesses the capability to trigger substantial immunosuppression by instigating inflammation in critical organs like the thymus and spleen. L-Ascorbic acid (L-AA) exhibits robust immunoregulatory prowess by orchestrating the epigenetic terrain through TET and JHDM pathways. Conversely, α-tocopherol (α-T) demonstrates the capacity to dampen the production of pro-inflammatory cytokines by modulating the PI3K-Akt axis. Given these insights, this inquiry embarks on exploring the mitigative potential of L-AA and α-T co-supplementation at the transcriptome level within leukocytes under arsenic exposure. Concurrently, the research endeavours to unravel the potent anti-inflammatory effects of administering α-T and L-AA, alleviating inflammation within the spleen and thymus amidst arsenic-induced insult and delving deeply into their immunomodulatory mechanisms. The rats were randomly allocated into eight distinct groups for subsequent experimentation: (I) the control group was administered solely with distilled water as the vehicle (control); (II) NaAsO

Indexed as

alpha-TocopherolArsenicAscorbic AcidInflammationLeukocytesSpleenThymus GlandAnimalsDietary SupplementsMaleRatsalpha-TocopherolArsenicAscorbic AcidInflammationL-ascorbic acid and α-tocopherolLeukocyte infiltrationThymus and spleenTranscriptomics analysis

Identifiers

PMID39325335

DOI10.1159/000088116

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.