Evidence map›Paper›PMID 39325233›Full record

ArticleMolecular biology reports2024

Clinical characteristics and thrombophilia associated gene variants in Egyptians with unprovoked venous thromboembolism: three centers experience.

Alaa Efat, Sabry Shoeib, Abdelmonem Ahmed Abdelmonem, Medhat Maher Elamawy, Hiam Abdallah Eleleimy, Reda Abdelatif Ibrahem, Suzan M Elmorshedy, Mona Mahrous Abdelaty

Abstract readMulticenter Study
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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Alaa EfatHematology unit, Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebin Al-Kom, Menoufia, Egypt. alaaefat23@gmail.com.ORCID https://orcid.org/0000-0001-8148-3443
Sabry ShoeibHematology unit, Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebin Al-Kom, Menoufia, Egypt.
Abdelmonem Ahmed AbdelmonemHematology unit, Internal Medicine Department, Faculty of Medicine, Benha University, Benha, Egypt.
Medhat Maher ElamawyHematology unit, Internal Medicine Department, Faculty of Medicine, Benha University, Benha, Egypt.
Hiam Abdallah EleleimyHematology unit, Internal Medicine Department, Faculty of Medicine, Benha University, Benha, Egypt.
Reda Abdelatif IbrahemPublic Health and Community Medicine Department, Faculty of Medicine, Menoufia University, Shebin Al-Kom, Menoufia, Egypt.
Suzan M ElmorshedyClinical Pathology Department, National Liver Institute, Menoufia University, Shebin Al-Kom, Menoufia, Egypt.
Mona Mahrous AbdelatyHematology unit, Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThrombophilias are characterized by excessive venous and arterial thrombosis at regular or unusual sites. It may result from inherited, acquired, or a combination. Hereditary thrombophilia (HT) is detected in 30-40% of patients with thromboembolism. Venous/arterial thrombosis is considered a multifactorial disorder, some patients may have more than one risk factor which may be transient or permanent.

objectivesAssess the clinical characteristics of patients with unprovoked thromboembolic events and the role of inherited thrombophilia as a causative or additive risk factor.

methods210 consecutive adult patients with unprovoked thromboembolic events were reviewed in hematology units at three tertiary Egyptian centers between September 2022 and September 2023. The diagnosis of thromboembolic events was confirmed by clinical and radiological findings. Laboratory screening for thrombophilia-associated.

resultsAmong our patients, 53(25.2%) patients presented with isolated DVT, followed by portal vein thrombosis, 32(15.2%) had a pulmonary embolism, and sagittal sinus thrombosis was developed in 23(10.9%) patients.

conclusionYounger people who experience spontaneous thromboembolism run the chance of having hereditary thrombophilia; the more mutations discovered, the higher the risk of thrombosis; the lower leg and deep vein thrombosis were the most common sites. Lastly, MTHFR C677T was the most common polymorphism in Egyptians, detected in almost half of the cases.

Indexed as

ThrombophiliaVenous ThromboembolismAdultAgedEgyptFemaleGenetic Predisposition to DiseaseHumansMaleMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedMutationNorth African PeoplePulmonary EmbolismRisk FactorsYoung AdultMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanDeep venous thrombosisFactor V LeidenInheritedThromboembolismThrombophilia

Identifiers

PMID39325233

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