Trial reportLasers in medical science2024
Prospective study of using 1064-nm Q-switched Nd: YAG combined with radiofrequency-imported vitamin C on pigmented infraorbital dark circles.
Trial report in Lasers in medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinical Applications of Vitamin C in Dermatology: A Systematic Review.The Journal of clinical and aesthetic dermatology · 2026Review
- A Real-World Study of Polynucleotides HPT for Treating Periorbital Hyperpigmentation.Clinical, cosmetic and investigational dermatology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Infraorbital dark circles are a common manifestation of periorbital melanosis, which is aesthetically defective and bring a negative impact on life quality. However, there is no acknowledged treatment for infraorbital dark circles. The 1064-nm Q-switched Nd: YAG laser (QSNYL) is commonly utilized to treat hyperpigmentation disorders. Radiofrequency (RF) therapy can improve the transdermal absorption rate of drugs. A prospective clinical trial was conducted to investigate the clinical efficacy and safety of 1064-nm QSNYL combined with RF-imported vitamin C for the treatment of infraorbital dark circles. A questionnaire was used to explore the relevant factors affecting the severity of infraorbital dark circles. A total of 30 patients with pigmented infraorbital dark circles were enrolled in this clinical trial. Each participant received 4 treatments and was followed up for at least 12 months after the last treatment.We focused on the overall change in the appearance of the included participants before and after treatment, by using satisfaction evaluation.In order to reduce evaluation bias, the vivo reflectance confocal microscopy images were taken on days 1 and 120 to detect pigmentation. The questionnaire survey before treatment showed that high-frequency makeup was positively and statistically significant with the severity of infraorbital dark circles (p < 0.01). Both participants and independent evaluators found that the hyperpigmentation in the infraorbital region was significantly reduced after combined treatment with high treatment satisfaction. The density of melanin particles in the infraorbital dark circles region showed a decreased trend. No significant side effects were observed. The 1064-nm QSNYL combined with RF-imported vitamin C is a safe and effective treatment for pigmented infraorbital dark circles by reducing melanin particles.
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Registered trials
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