Evidence map›Paper›PMID 39325099›Full record

ArticleEuropean journal of nutrition2024

EGCG suppressed activation of hepatic stellate cells by regulating the PLCE1/IP

Ying Lin, Yan Zhang, Yang Li, Qihan Xu, Yijie Zhang, Tingting Chen, Jun Wang, Jierui Li, Jiacheng Gong, Zhuoer Chen and 2 more

Abstract read
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In one paragraph

Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ying Lin *Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.
Yan Zhang *Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.
Yang Li *Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.
Qihan XuDepartment of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.
Yijie ZhangDepartment of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.
Tingting ChenDepartment of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.
Jun WangDepartment of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.
Jierui LiDepartment of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.
Jiacheng GongDepartment of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.
Zhuoer ChenDepartment of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.
Qiaomu YangDepartment of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.
Xu LiDepartment of Emergency Medicine, Nanfang Hospital, Southern Medical University, No. 1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China. mylx99@smu.edu.cn.

Funding

National Natural Science Foundation of China 82170641Natural Science Foundation of Guangdong Province 2021A1515012595Youth Fund of National Natural Science Foundation of China 82100660
6 · The paper itself

Abstract

(-)-Epigallocatechin-3-O-gallate (EGCG), one of the green tea catechins, exhibits significant antioxidant properties that play an essential role in various diseases. However, the functional role and underlying mechanism of EGCG in stimulating of hepatic stellate cells (HSCs) remain unexplored in transcriptomics sequencing studies. The present study suggests that oral administration of EGCG at a dosage of 200 mg/kg/day for a duration of four weeks exhibits significant therapeutic potential in a murine model of liver fibrosis induced by CCl

Indexed as

CalciumCatechinHepatic Stellate CellsInositol 1,4,5-TrisphosphateAnimalsAntioxidantsCalcium SignalingCell ProliferationLiver CirrhosisMaleMiceMice, Inbred C57BLPhosphoinositide Phospholipase CAntioxidantsCalciumCatechinepigallocatechin gallateInositol 1,4,5-TrisphosphatePhosphoinositide Phospholipase CEGCGHepatic stellate cellsLiver fibrosisPLCE1/IP3/Ca2+ pathway

Identifiers

PMID39325099

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.