Evidence map›Paper›PMID 39324935›Full record

ArticleClinical transplantation2024

Interplay of Donor-Recipient Relationship and Donor Race in Living Liver Donation in the United States.

Abdula Al-Seraji, Simeon Adeyemo, Ahmet Gurakar, Riya Shah, Suphamai Bunnapradist, Krista L Lentine, Robert R Redfield, Merve Gurakar, Alpesh N Amin, Abimereki D Muzaale and 3 more

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Article in Clinical transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Abdula Al-SerajiDepartment of Medicine, University of California Irvine, Orange, California, USA.
Simeon AdeyemoDepartment of Medicine, University of California Irvine, Orange, California, USA.
Ahmet GurakarDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-2221-9148
Riya ShahDepartment of Public Health, University of Southern California, Los Angeles, California, USA.
Suphamai BunnapradistDepartment of Medicine, University of California, Los Angeles, California, USA.
Krista L LentineDepartment of Internal Medicine, Saint Louis University, St. Louis, Missouri, USA.ORCID 0000-0002-9423-4849
Robert R RedfieldDepartment of Surgery, University of California Irvine, Orange, California, USA.
Merve GurakarDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Alpesh N AminDepartment of Medicine, University of California Irvine, Orange, California, USA.
Abimereki D MuzaaleDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-3287-6061
Abhinav HumarDepartment of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Fawaz Al AmmaryDepartment of Medicine, University of California Irvine, Orange, California, USA.ORCID 0000-0003-0928-2860
Saleh A AlqahtaniDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-2017-3526

Funding

Telemedicine for Evaluation and Counseling of Living Kidney Donor CandidatesK23DK129820 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI AL AMMARY, FAWAZ · 2021 to 2025
$985k
Perioperative and long-term risks following nephrectomy in older live kidney donorsK08AG065520 · NIA · JOHNS HOPKINS UNIVERSITY · PI MUZAALE, ABIMEREKI D · 2020 to 2024
$855k
NHLBI NIH HHSNIA NIH HHS K08 AG065520NIA NIH HHS K08AG065520-01NIA NIH HHS K23DK129820NIDDK NIH HHS K23 DK129820
6 · The paper itself

Abstract

introductionLiving liver donation improves survival of end-stage liver disease (ESLD) patients. Yet, it continues to represent a small proportion of United States (U.S.) liver transplantation with existing racial disparities. We investigated the interplay of donor-recipient relationship and donor race to understand donor subgroups with no significant increase.

methodsWe studied 4407 living liver donors in the U.S. from January 1, 2012, to December 31, 2022 (median age = 36 years, and 59% were biologically related to the recipient). We quantified the change in the number of donors per 3-year increment using negative binomial regression (incidence rate ratio [IRR]), stratified by donor-recipient relationship and race/ethnicity.

resultsAmong biologically related donors, the observed annual number of White donors increased from 146 to 253, Hispanic donors from 18 to 53, and Black donors decreased from 11 to 10. Among unrelated donors, White donors increased from 65 to 221, Hispanic donors from 4 to 25, and Black donors from 3 to 11. For the IRR of biologically related donors aged <40 and ≥40 years, White donors increased by 18% and 22%; Hispanic donors increased by 25% and 54%; and Black donors did not change. Likewise, the IRR of unrelated donors aged <40 and ≥40 years, White donors increased by 48% and 55%; Hispanic donors increased by 52% and 65%; and Black donors did not change.

conclusionsWhile biologically related donors represent the majority of donors, unrelated donors have substantially risen in recent years, primarily driven by White donors. Although the rate of unrelated donations increased among Hispanic donors, the absolute number remains very small (≤25 donors/year). Interventions are needed to increase education among Hispanic and Black communities to grow unrelated living liver donations across race/ethnicity.

Indexed as

Liver TransplantationLiving DonorsAdultEnd Stage Liver DiseaseFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRacial GroupsTissue and Organ ProcurementTransplant RecipientsUnited StatesYoung Adultfamilyhepatectomyliverliving donorsracial groupsregistry

Identifiers

PMID39324935
PMCPMC13618735

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.