ArticleAntimicrobial agents and chemotherapy2024
Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy.
Emily Puumala, Sunna Nabeela, Christopher C Thornburg, Tanja Grkovic, Priya Uppuluri, Luke Whitesell, Barry R O'Keefe, Nicole Robbins, Leah E Cowen
Abstract read
In one paragraphArticle in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Sunna NabeelaDivision of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles Medical Center, Torrance, California, USA.
Christopher C ThornburgNatural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Tanja GrkovicNatural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland, USA.
Priya UppuluriDivision of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles Medical Center, Torrance, California, USA.ORCID 0000-0002-5889-054X Luke WhitesellDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Barry R O'KeefeNatural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland, USA.
Nicole RobbinsDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Funding
NCI Program for Natural Products Discovery - CuresZIABC011854 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI OKEEFE, BARRY · 2020 to 2025
$5.2MTargeting the regulatory mechanism of hyphae to lateral yeast growth as a novel therapeutic approach against candidiasisR01AI141794 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI UPPULURI, PRIYA · 2019 to 2022
$1.5MCanadian Government | Canadian Institutes of Health Research (CIHR) FDN-154288CCR NIH HHS HHSN261200800001CHHS | National Institutes of Health (NIH) R01AI141794HHS | NIH | National Cancer Institute (NCI) ZIA BC 011854Intramural NIH HHS ZIA BC011854NCI NIH HHS HHSN261200800001ENIAID NIH HHS R01 AI141794
6 · The paper itselfAbstract
Fungal disease affects over a billion people worldwide. Naamidine A inhibits the growth of diverse fungal pathogens through an unknown mechanism. Here, we show that the supplementation of medium with excess zinc abolishes the antifungal activity of naamidine A. Furthermore, we highlight that naamidine A has
Indexed as
Administration, TopicalAntifungal AgentsMicrobial Sensitivity TestsZincAnimalsArthrodermataceaeDermatomycosesDisease Models, AnimalDrug Resistance, FungalHumansMiceTerbinafineTineaTrichophytonAntifungal AgentsTerbinafineZincCandida albicansdermatomycosisdrug-resistantmetal chelationnatural productTrichophytonzinc
Identifiers
PMID39324798
PMCPMC11539223
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