SynthesisPeriodontology 20002025
Periodontal regeneration using platelet-rich fibrin. Furcation defects: A systematic review with meta-analysis.
Synthesis in Periodontology 2000, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Platelet-rich plasma (PRP) versus injectable platelet-rich fibrin (i-PRF): A systematic review across all fields of medicine.Periodontology 2000 · 2025Pooled it
- Periodontal regeneration using platelet-rich fibrin. Furcation defects: A systematic review with meta-analysis.Periodontology 2000 · 2025Pooled it
- Comparative Efficacy of Platelet-Rich Fibrin and Enamel Matrix Derivative As Adjuncts to Non-Surgical Periodontal Therapy: A Split-Mouth Randomised Clinical Trial.Oral health & preventive dentistry · 2026Trial
- Effect of injectable platelet-rich fibrin on orthodontically induced apical root resorption following non-extraction-based orthodontic treatment in adults: A randomized controlled clinical trial.The Journal of international medical research · 2026Trial
- Assessment of periodontal regeneration with blood derivatives: a systematic review and network meta-analysis.Odontology · 2026Review
- Review
- DFDBA plus T-PRF with and without vitamin D3 gel in intrabony defects: a randomized controlled trial.Odontology · 2026Article
- Platelet Concentrates in Periodontal Regeneration: A Review of Current Evidence and Clinical Perspectives.Cureus · 2026Review
- Article
- Preclinical Evaluation of the Effect of Liquid Platelet-Rich Fibrin and a Volume-Stable Collagen Matrix on Periodontal Regeneration.Journal of clinical periodontology · 2026Article
- The Feasibility of Exosome-Enriched Platelet-rich Fibrin (PRF) for the Treatment of Gingival Recessions: A Case Series of 27 Patients.Oral health & preventive dentistry · 2026Article
- Article
- Xenografts and platelet-rich fibrin impact on maxillary sinus augmentation: A comparative clinical histomorphometric study.Bioinformation · 2026Article
- Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay.Frontiers in immunology · 2026Article
- Refrigerated storage of L-PRF membranes: anti-bacterial activity, cytokine release, andFrontiers in oral health · 2026Article
- Comparative evaluation of platelet-rich fibrin and collagen membrane for guided bone regeneration in alveolar defects.Bioinformation · 2026Article
- Comparative assessment of injectable platelet-rich fibrin versus concentrated growth factor for periodontal intrabony defects.Bioinformation · 2026Article
- Digitally Guided Modified Intentional Replantation for a Tooth with Hopeless Periodontal Prognosis: A Case Report.Diagnostics (Basel, Switzerland) · 2025Article
- Use of liquid platelet-rich fibrin (liquid PRF) in temporomandibular joint disorders: A narrative review with clinical recommendations.Periodontology 2000 · 2025Review
- Diagnostic and Clinical Outcomes of Three Regenerative Strategies for Alveolar Bone Defects: A Comparative Study Using CBCT and ISQ.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the study was to compare the treatment outcomes of periodontal furcation defects by using platelet-rich fibrin (PRF) with other commonly utilized modalities. The eligibility criteria comprised randomized controlled trials (RCTs) comparing the clinical outcomes of PRF with those of other modalities for the treatment of furcation defects. Studies were classified into 11 categories in 3 different groups as follows: Group I (addition of PRF): (1) open flap debridement (OFD) alone versus OFD/PRF, (2) OFD/bone graft (OFD/BG) versus OFD/BG/PRF; Group II (comparative studies to PRF): (3) OFD/BG versus OFD/PRF, (4) OFD/collagen membrane versus OFD/PRF, (5) OFD/PRP versus OFD/PRF, (6) OFD/rhBMP2 versus OFD/PRF; and Group III (addition of biomaterial/biomolecule to PRF): OFD/PRF versus … (7) OFD/PRF/BG, (8) OFD/PRF/amniotic membrane (AM), (9) OFD/PRF/metformin, (10) OFD/PRF/bisphosphonates, (11) OFD/PRF/statins. Weighted means and forest plots were calculated for the reduction of probing pocket depth (PPD), gain of vertical and horizontal clinical attachment levels (VCAL and HCAL), gain in vertical and horizontal bone levels (VBL, HBL), and radiographic bone fill (RBF). From 45 articles identified, 21 RCTs reporting on class II furcations were included. The use of OFD/PRF and OFD/BG/PRF statistically significantly reduced PPD and improved VCAL and HCAL when compared to OFD or OFD/BG, respectively. The comparison between OFD/PRF alone versus OFD/BG, OFD/CM, OFD/PRP, or OFD/rhBMP2 led to similar outcomes for all investigated parameters, including a reduction in PPD, VCAL/HCAL gain, and RBF. The additional incorporation of a BG to OFD/PRF only mildly improved outcomes, whereas the addition of AM improved clinical outcomes. The addition of small biomolecules such as metformin, bisphosphonates, or statins all led to significant improvements in PPD, VCAL, and HCAL when compared to OFD/PRF alone. Noteworthy, a very high heterogeneity was found in the investigated studies. The use of PRF significantly improved clinical outcomes in class II furcation defects when compared to OFD alone, with similar levels being observed between OFD/PRF and/or OFD/BG, OFD/CM, OFD/PRP, or OFD/rhBMP2. Future research geared toward better understanding potential ways to enhance the regenerative properties of PRF with various small biomolecules may prove valuable for future clinical applications. Future histological research investigating PRF in human furcation defects is largely needed. The use of PRF in conjunction with OFD statistically significantly improved PPD, VCAL, and HCAL values, yielding comparable outcomes to commonly used biomaterials. The combination of PRF to bone grafts or the addition of small biomolecules may offer additional clinical benefits, thus warranting future investigation.
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