ArticleJournal of animal science2024
Dietary curcumin supplementation enhances growth performance and anti-inflammatory functions by modulating gut microbiota, microbiota-derived metabolites, and expression of inflammation-related genes in broilers.
Article in Journal of animal science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of dietary curcumin supplementation on growth performance, intestinal morphology, and antioxidant status in weaned piglets: a meta-analysis.Frontiers in veterinary science · 2026Pooled it
- Polyphenols regulate bone health through the gut-bone axis: molecular and applications in animal nutrition.Journal of animal science and biotechnology · 2026Review
- Curcumin ameliorates fatty liver hemorrhagic syndrome in broiler breeders by regulating lipid metabolism via the gut-liver axis.Poultry science · 2026Article
- Article
- Curcumin modulates targeted gut bacterial populations and NF-κB/NRF2 immune-redox responses in Eimeria-challenged broilers fed soybean or canola oil.Scientific reports · 2026Article
- Curcumin as a Green Antibiotic Substitute: Mechanisms and Applications in Poultry Production and Health Promotion.Animals : an open access journal from MDPI · 2026Review
- Meta-Analysis of Dietary Curcumin Supplementation in Broiler Chickens: Growth Performance, Antioxidant Status, Intestinal Morphology, and Meat Quality.Antioxidants (Basel, Switzerland) · 2025Article
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Curcumin (CUR) is a natural polyphenolic substance that has been widely used since ancient times for its multiple beneficial functions. However, whether CUR affects the growth performance of broilers by altering gut microbiota and metabolite and the underlying mechanism are largely unknown. This study was conducted to evaluate the effect of dietary CUR supplementation on growth performance, anti-inflammatory function, intestinal morphology and barrier, cecum microbiota, and metabolite profile of broilers. Sixty-one-day-old male broilers were randomly divided into the control group (CON, fed a control diet) and the CUR group (fed a control diet supplemented with 200 mg/kg CUR) after 2 d of adaptation. Results showed that after feeding to 52-d-old, compared with CON broilers, the CUR broilers showed improved feed utilization efficiency and growth performance. Furthermore, the CUR broilers showed an improved intestinal morphology, which was demonstrated by a lower crypt depth in the jejunum. The 16S rRNA gene sequencing and non-targeted metabonomics (LC-MS/MS) analysis results showed that the cecum microbiota ecology and function were significantly improved, and the abundance of beneficial flora and metabolites were increased, while the harmful bacteria and metabolites were significantly decreased. In addition, RT-qPCR results showed that CUR significantly reduced inflammatory responses, promoted the formation of the mucosal barrier and enhanced digestion, absorption, and transport of lipids and glucose-related gene expression in the intestine. These above findings demonstrated that dietary CUR supplementation improved growth performance, intestinal morphology, and anti-inflammatory functions, mainly by manipulating cecum microbiota and microbiota-derived metabolites, which provides a credible explanation for the growth-promoting effect and anti-inflammatory functions of CUR and aids our understanding of the mechanisms underlying.
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