ArticleArtificial organs2025
Impact of extracorporeal blood pump gap sizes on the performance and hemocompatibility under off-design operation.
Article in Artificial organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Comparison of a Miniaturized Implantable Two-Stage Rotodynamic Blood Pump to Equivalent Single-Stage Concepts.Artificial organs · 2026Article
- Impact of extracorporeal blood pump gap sizes on the performance and hemocompatibility under off-design operation.Artificial organs · 2025Article
- Optimization of secondary flow path clearance in centrifugal blood pump: a combined numerical and experimental study.Frontiers in physiology · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundHemocompatibility remains the dominant challenge in rotary blood pumps, and more information on the relationship between individual pump design features, hemodynamics, and blood trauma in various operation conditions is necessary. The study evaluated the variation of gap sizes in extracorporeal blood pumps concerning their influence on blood compatibility, particularly during off-design conditions.
methodsWe developed a parametric generic blood pump framework for in-silico and in-vitro design feature analysis. Thirty-six designs with varying axial and radial gap sizes between 0.5 mm and 3 mm were generated. CFD was applied to calculate and compare device hemodynamics and evaluate the performance and hemocompatibility during off-design and target operation conditions. The following quantities were analyzed: pressure difference, hemolysis potential, residence times, hydraulic efficiency, and recirculation ratio.
resultsThe in-vitro prototype showed excellent agreement with in-silico predictions regarding hydraulic performance (R
conclusionsWe introduced and showed the feasibility of a parametric rotary blood pump framework to systematically investigate design feature impact. Results suggest, larger and uniformly sized gaps being overall beneficial regarding hemocompatibility.
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