Evidence map›Paper›PMID 39324491›Full record

ArticleGut microbes

FMT rescues mice from DSS-induced colitis in a STING-dependent manner.

Dan Pu, Yao Yao, Chuan Zhou, Ruixian Liu, Zhihong Wang, Yan Liu, Dandan Wang, Binbin Wang, Yaohe Wang, Zhanju Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Gut microbes · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dan PuDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yao YaoDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chuan ZhouDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ruixian LiuDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhihong WangDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yan LiuDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Dandan WangDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Binbin WangDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yaohe WangNational Center for International Research in Cell and Gene Therapy, Sino-British Research Centre for Molecular Oncology, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Zhanju LiuDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhe ZhangDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0002-8973-3563
Baisui FengDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0001-9440-9285

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fecal microbiota transplantation (FMT) is currently a promising therapy for inflammatory bowel disease (IBD). However, clinical studies have shown that there is an obvious individual difference in the efficacy of FMT. Therefore, it is a pressing issue to identify the factors that influence the efficacy of FMT and find ways to screen the most suitable patients for this therapy. In this work, we targeted the stimulator of interferon genes (STING), a DNA-sensing protein that regulates host-defense. By comparing the differential efficacy of FMT in mice with different expression level of STING, it is revealed that FMT therapy provides treatment for DSS-induced colitis in a STING-dependent manner. Mechanistically, FMT exerts a regulatory effect on the differentiation of intestinal Th17 cells and macrophages, splenic Th1 and Th2 cells, as well as Th1 cells of the mesenteric lymph nodes via STING, down-regulating the colonic M1/M2 and splenic Th1/Th2 cell ratios, thereby improving the imbalanced immune homeostasis in the inflamed intestine. Meanwhile, based on the 16SrDNA sequencing of mice fecal samples, STING was found to facilitate the donor strain colonization in recipients' gut, mainly

Indexed as

ColitisDextran SulfateFecal Microbiota TransplantationGastrointestinal MicrobiomeMembrane ProteinsMice, Inbred C57BLAnimalsColonDisease Models, AnimalHumansMacrophagesMiceSTING ProteinTh17 CellsTh1 CellsTh2 CellsDextran SulfateMembrane ProteinsSTING1 protein, humanSting1 protein, mouseSTING ProteinFMTIBDLactobacillalesmacrophagesSTINGTh17 cellsTh1 cellsTh2 cells

Identifiers

PMID39324491
PMCPMC11441074

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.