Evidence map›Paper›PMID 39324432›Full record

ArticleActa obstetricia et gynecologica Scandinavica2025

Psychological and emotional profiles of Australian uterine transplant potential recipients: A comparison with international trials.

Brigitte Gerstl, Eva Kehag, Hayley Mallinder, Tamika Baker, Kaushalya Arulpragasam, Catherine David, Meredith Stone, Elizabeth Fitzsimmons, Kate Hetherington, Rebecca Deans

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A decade of human uterus transplantation.Acta obstetricia et gynecologica Scandinavica · 2025
    Article
  2. Article
  3. Article
  4. Past, Present, and Future: A Review of Uterus Transplant.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brigitte GerstlRoyal Hospital for Women, Sydney, Australia.ORCID 0000-0003-1848-056X
Eva KehagRoyal Hospital for Women, Sydney, Australia.
Hayley MallinderFaculty of Medicine, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
Tamika BakerRoyal Hospital for Women, Sydney, Australia.
Kaushalya ArulpragasamGynecological Research and Clinical Evaluation (GRACE) Group, Royal Hospital for Women and University of New South Wales, Sydney, Australia.
Catherine DavidGynecological Oncology Department, Royal Hospital for Women, Sydney, Australia.
Meredith StonePerinatal Psychiatry and Women's Mental Health, Royal Hospital for Women, Sydney, Australia.
Elizabeth FitzsimmonsSocial Work Department, Royal Hospital for Women, Sydney, Australia.
Kate HetheringtonFaculty of Medicine, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
Rebecca DeansFaculty of Medicine, School of Clinical Medicine, University of New South Wales, Sydney, Australia.

Funding

Royal Hospital for Women Foundation
6 · The paper itself

Abstract

introductionUterus transplant (UTx) has emerged as a groundbreaking solution for individuals with uterine factor infertility (UFI). This study is the first in Australia to explore the psychosocial functioning of potential recipients assessed for the nation's initial UTx clinical trial and to compare their psychological profiles with those from international UTx trials. MATERIAL AND

methodsThis is a mixed methods prospective study incorporating standardized psychological measures and semi-structured interviews. Conducted at a tertiary hospital in Sydney, Australia, the study involved 10 female Australian UTx potential recipients with UFI undergoing assessment for UTx surgery. Participants underwent comprehensive psychological evaluation using validated measures and in-depth semi-structured interviews. Quantitative measurement tools included the Hospital Anxiety and Depression Scale, Short Form-36 Health Survey, Fertility Quality of Life, and the Stanford Integrated Psychosocial Assessment for Transplantation. Thematic analysis was conducted on qualitative data from semi-structured interviews.

resultsThe Australian UTx potential recipients reported significantly higher Short Form-36 (SF-36) scores compared to the Australian general population in general health (p < 0.04), bodily pain (p < 0.02), social functioning (p < 0.02), and emotional well-being (p < 0.01). Compared with international UTx cohorts, the Australian UTx group showed comparable SF-36 outcomes, with minor variations observed for general health and physical function domains. Hospital Anxiety and Depression Scale scores revealed lower anxiety, but slightly higher depression levels compared to international UTx trial cohorts. Fertility quality-of-life scores were significantly higher in the Australian UTx group compared to women experiencing primary infertility across four domains (p < 0.001). Thematic analysis of interviews highlighted the complex emotional impact of infertility, strong family and social support, and the perception of UTx as a transformative opportunity to achieve wholeness and motherhood.

conclusionsUTx represents a novel treatment option for women with UFI. This is the first qualitative study in Australia, it demonstrates the connection between women with UFI and their motivations for parenthood. These findings highlight the importance of tailored psychological assessments and establish a foundation for future research exploring the psychological characteristics of patient candidacy for UTxs.

Indexed as

Infertility, FemaleQuality of LifeUterusAdultAnxietyAustraliaDepressionFemaleHumansProspective StudiesinfertilityMayer–Rokitansky–Küster–Hauser (MRKH) syndromepsychological healthquality of lifeuterine factor infertilityuterus transplantation

Identifiers

PMID39324432
PMCPMC11871097

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.