Evidence map›Paper›PMID 39324422›Full record

Observational studyHIV medicine2025

Long-term risk of mortality and loss to follow-up in children and adolescents on antiretroviral therapy in Asia.

Smita Nimkar, Aarti Kinikar, Vidya Mave, Vohith Khol, Quy Tuan Du, Lam Nguyen, Pradthana Ounchanum, Dinh Qui Nguyen, Thanyawee Puthanakit, Pope Kosalaraks and 14 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in HIV medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Smita NimkarB J Govt Medical College - Johns Hopkins University, Clinical Research Site, Pune, India.ORCID https://orcid.org/0000-0002-7208-7729
Aarti KinikarB J Govt Medical College - Johns Hopkins University, Clinical Research Site, Pune, India.
Vidya MaveB J Govt Medical College - Johns Hopkins University, Clinical Research Site, Pune, India.
Vohith KholNational Centre for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia.
Quy Tuan DuInfectious Diseases Department, Children's Hospital 1, Ho Chi Minh City, Vietnam.
Lam NguyenInfectious Diseases Department, National Hospital of Pediatrics, Hanoi, Vietnam.
Pradthana OunchanumDepartment of Pediatrics, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand.
Dinh Qui NguyenInfectious Disease Department, Children's Hospital 2, Ho Chi Minh City, Vietnam.
Thanyawee PuthanakitDepartment of Pediatrics and Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Pope KosalaraksDivision of Infectious Disease, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Kulkanya ChokephaibulkitDepartment of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tavitiya SudjaritrukDivision of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID https://orcid.org/0000-0002-3686-4623
Dina MuktiartiFaculty of Medicine, Dr. Cipto Mangunkusumo-Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.ORCID https://orcid.org/0000-0002-0828-3354
Nagalingeswaran KumarasamyVHS-Infectious Diseases Medical Centre, Chennai, India.
Nik Khairulddin Nik YusoffDepartment of Pediatrics, Hospital Raja Perempuan Zainab II, Kota Bharu, Malaysia.
Thahira MohamedDepartment of Pediatrics, Women and Children Hospital Kuala Lumpur (WCHKL), Kuala Lumpur, Malaysia.
Dewi WatiFaculty of Medicine, Udayana University-Prof. Dr. I.G.N.G. Ngoerah Hospital, Bali, Indonesia.
Anggraini AlamFaculty of Medicine, Hasan Sadikin General Hospital, Bandung, Indonesia.
Siew FongDepartment of Pediatrics, Hospital Likas, Kota Kinabalu, Malaysia.
Revathy NallusamyDepartment of Pediatrics Penang Hospital, Penang, Malaysia.
Tulathip SuwanlerkTREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
Annette SohnTREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
Azar KariminiaThe Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
TREAT Asia Pediatric HIV Observational Database of IeDEA Asia‐Pacific

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
National Institutes of Health's National Institute of Allergy and Infectious Diseases,NCI NIH HHSNHLBI NIH HHSNIAAA NIH HHSNIAID NIH HHS U01 AI069907NIDA NIH HHSNIMH NIH HHSthe Eunice Kennedy Shriver National Institute of Child Health and Human Developmentthe Fogarty International Center, as part of the International epidemiology Databases to Evaluate AIDSThe Kirby Institute funded by the Australian Government Department of Health and Ageingthe National Institute of Diabetes and Digestive and Kidney Diseases,TREAT Asia, a program of amfAR, The Foundation for AIDS Research
6 · The paper itself

Abstract

objectiveWe described mortality and loss to follow-up (LTFU) in children and adolescents who were under care for more than 5 years following initiation of antiretroviral therapy (ART).

methodsPatients were followed from 5 years after ART until the earlier of their 25th birthday, last visit, death, or LTFU. We used Cox regression to assess predictors of mortality and competing risk regression to assess factors associated with LTFU.

resultsIn total, 4488 children and adolescents initiating ART between 1997 and 2016 were included in the analysis, with a median follow-up time of 5.2 years. Of these, 107 (2.2%) died and 271 (6.0%) were LTFU. Mortality rate was 4.35 and LTFU rate 11.01 per 1000 person-years. Increased mortality was associated with AIDS diagnosis (adjusted hazard ratio [aHR] 1.71; 95% confidence interval [CI] 1.24-2.37), current CD4 count <350 cells/mm

conclusionFor children and adolescents surviving 5 years on ART, both current CD4 and viral load remained strong indicators that help to keep track of their treatment outcomes. More effort should be made to monitor patients who switch treatments.

Indexed as

Antiretroviral Therapy, Highly ActiveLost to Follow-UpAdolescentAsiaChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMaleRisk FactorsTime FactorsTreatment OutcomeHIV‐infected children and adolescentslong‐term ARTloss to follow‐upmortality

Identifiers

PMID39324422
PMCPMC11931730

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.