ArticleDevelopment (Cambridge, England)2024
Robust organ size in Arabidopsis is primarily governed by cell growth rather than cell division patterns.
Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- ROS inhibits microtubule dynamics and cell growth heterogeneity during Arabidopsis sepal morphogenesis.iScience · 2026Article
- Spatial and single-cell transcriptomics uncover brassinosteroid-mediated coordination of sepal elongation in Arabidopsis.Genome biology · 2026Article
- The impact of genome duplication on agronomically valuable traits in Ribes nigrum L.: a morpho-anatomical, physiological and cytogenetic evaluation.BMC plant biology · 2026Article
- Self-organization underlies developmental robustness in plants.Cells & development · 2025Review
- Fibrous network nature of plant cell walls enables tunable mechanics for development.Nature communications · 2025Article
- JAG modulates sepal flatness by regulating cell growth direction, interacts with AS2, and is antagonized by TCP24.Cell reports · 2025Article
- Stochastic gene expression in auxin signaling in the floral meristem of Arabidopsis thaliana.Nature communications · 2025Article
- FD and FDP bZIP transcription factors and FT florigen regulate floral development and control homeotic gene expression in Arabidopsis floral meristems.Development (Cambridge, England) · 2025Article
- Robust organ size in Arabidopsis is primarily governed by cell growth rather than cell division patterns.Development (Cambridge, England) · 2024Article
- Sepal shape variability is robust to cell size heterogeneity inBiology letters · 2024Article
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Abstract
Organ sizes and shapes are highly reproducible, or robust, within a species and individuals. Arabidopsis thaliana sepals, which are the leaf-like organs that enclose flower buds, have consistent size and shape, indicating robust development. Cell growth is locally heterogeneous due to intrinsic and extrinsic noise. To achieve robust organ shape, fluctuations in cell growth must average to an even growth rate, which requires that fluctuations are uncorrelated or anti-correlated in time and space. Here, we live image and quantify the development of sepals with an increased or decreased number of cell divisions (lgo mutant and LGO overexpression, respectively), a mutant with altered cell growth variability (ftsh4), and double mutants combining these. Changes in the number of cell divisions do not change the overall growth pattern. By contrast, in ftsh4 mutants, cell growth accumulates in patches of over- and undergrowth owing to correlations that impair averaging, resulting in increased organ shape variability. Thus, we demonstrate in vivo that the number of cell divisions does not affect averaging of cell growth, preserving robust organ morphogenesis, whereas correlated growth fluctuations impair averaging.
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