Evidence map›Paper›PMID 39324228›Full record

ArticleDevelopment and psychopathology2025

Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology.

Benjamin M Rosenberg, João F Guassi Moreira, Adriana S Méndez Leal, Natalie M Saragosa-Harris, Elizabeth Gaines, Wesley J Meredith, Yael Waizman, Emilia Ninova, Jennifer A Silvers

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In one paragraph

Article in Development and psychopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin M RosenbergDepartment of Psychology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-5346-6889
João F Guassi MoreiraDepartment of Psychology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-8312-4487
Adriana S Méndez LealDepartment of Psychology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-0147-9450
Natalie M Saragosa-HarrisDepartment of Psychology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-4493-6113
Elizabeth GainesDepartment of Psychology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Wesley J MeredithDepartment of Psychology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Yael WaizmanDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-8031-491X
Emilia NinovaCollege of Social Work, Florida State University, Tallahassee, FL, USA.
Jennifer A SilversDepartment of Psychology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-6615-5473

Funding

PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Doctoral Training in Brain and Behavioral Development During Adolescence (UCLA BBDA)T32HD091059 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mirella Dapretto, ANDREW J FULIGNI · 2018 to 2026
$1.7M
NICHD NIH HHS T32 HD091059NIMH NIH HHS T32 MH015750
6 · The paper itself

Abstract

backgroundReward and threat processes work together to support adaptive learning during development. Adolescence is associated with increasing approach behavior (e.g., novelty-seeking, risk-taking) but often also coincides with emerging internalizing symptoms, which are characterized by heightened avoidance behavior. Peaking engagement of the nucleus accumbens (NAcc) during adolescence, often studied in reward paradigms, may also relate to threat mechanisms of adolescent psychopathology.

methods47 typically developing adolescents (9.9-22.9 years) completed an aversive learning task during functional magnetic resonance imaging, wherein visual cues were paired with an aversive sound or no sound. Task blocks involved an escapable aversively reinforced stimulus (CS+

resultsFunctional connectivity between the NAcc and amygdala differentiated the stimuli, such that connectivity increased for the CS+

conclusionsAdolescents show heightened NAcc-amygdala functional connectivity during escape from threat. Higher anxiety and depression symptoms are associated with elevated NAcc-amygdala connectivity during safety, which may reflect poor safety versus threat discrimination.

Indexed as

AmygdalaAvoidance LearningNucleus AccumbensAdolescentAnxietyChildFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysYoung AdultAdolescenceanxietydepressionfunctional connectivitythreat learning

Identifiers

PMID39324228
PMCPMC11936845

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.