Evidence map›Paper›PMID 39324186›Full record

ArticleCirculation2024

Associations of "Weekend Warrior" Physical Activity With Incident Disease and Cardiometabolic Health.

Shinwan Kany, Mostafa A Al-Alusi, Joel T Rämö, James P Pirruccello, Timothy W Churchill, Steven A Lubitz, Mahnaz Maddah, J Sawalla Guseh, Patrick T Ellinor, Shaan Khurshid

Abstract read
In one paragraph

Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  17. Evolution in the targets for blood pressure treatment.Current opinion in nephrology and hypertension · 2026
    Review
  18. Effect of exercise and physical activity on blood pressure reduction.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  19. Accelerometer-measured weekly and diurnal moderate-to-vigorous physical activity patterns and incident osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shinwan KanyDepartment of Cardiology, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany (S. Kany).ORCID 0000-0001-8113-733X
Mostafa A Al-AlusiCardiovascular Disease Initiative (S. Kany, M.A.A.-A., J.T.R., J.P.P., S.A.L., P.T.E., S. Khurshid), Broad Institute of MIT and Harvard, Cambridge.ORCID 0000-0002-9359-1641
Joel T RämöCardiovascular Disease Initiative (S. Kany, M.A.A.-A., J.T.R., J.P.P., S.A.L., P.T.E., S. Khurshid), Broad Institute of MIT and Harvard, Cambridge.ORCID 0000-0002-6429-5149
James P PirruccelloCardiovascular Disease Initiative (S. Kany, M.A.A.-A., J.T.R., J.P.P., S.A.L., P.T.E., S. Khurshid), Broad Institute of MIT and Harvard, Cambridge.ORCID 0000-0001-6088-4037
Timothy W ChurchillCardiovascular Research Center (S. Kany, M.A.A.-A., J.T.R., T.W.C., S.A.L., J.S.G., P.T.E., S. Khurshid), Massachusetts General Hospital, Boston.ORCID 0000-0002-0215-3049
Steven A LubitzCardiovascular Disease Initiative (S. Kany, M.A.A.-A., J.T.R., J.P.P., S.A.L., P.T.E., S. Khurshid), Broad Institute of MIT and Harvard, Cambridge.ORCID 0000-0002-9599-4866
Mahnaz MaddahData Sciences Platform (M.M.), Broad Institute of MIT and Harvard, Cambridge.ORCID 0000-0002-9837-6000
J Sawalla GusehCardiovascular Research Center (S. Kany, M.A.A.-A., J.T.R., T.W.C., S.A.L., J.S.G., P.T.E., S. Khurshid), Massachusetts General Hospital, Boston.ORCID 0000-0003-0992-5635
Patrick T Ellinor *Cardiovascular Disease Initiative (S. Kany, M.A.A.-A., J.T.R., J.P.P., S.A.L., P.T.E., S. Khurshid), Broad Institute of MIT and Harvard, Cambridge.ORCID 0000-0002-2067-0533
Shaan Khurshid *Cardiovascular Disease Initiative (S. Kany, M.A.A.-A., J.T.R., J.P.P., S.A.L., P.T.E., S. Khurshid), Broad Institute of MIT and Harvard, Cambridge.ORCID 0000-0002-2840-4539

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
Institutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7M
Genomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3M
Using Electrocardiogram Genetics to Inform Arrhythmia RiskR01HL157635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS, MIRSHAHI, TOORAJ · 2022 to 2025
$2.9M
Aortic Dilatation in Endurance Athletes: A Physiologic and Mechanistic StudyK23HL159262 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Timothy CHURCHILL · 2022 to 2026
$983k
Electrocardiogram-based deep learning and decision analysis to improve atrial fibrillation risk estimationK23HL169839 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Shaan Khurshid · 2023 to 2026
$860k
Deep learning to enable the genetic analysis of aortaK08HL159346 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PIRRUCCELLO, JAMES · 2021 to 2025
$827k
American Heart Association-American Stroke Association 23CDA1050571NCATS NIH HHS KL2 TR002542NHLBI NIH HHS K08 HL159346NHLBI NIH HHS K23 HL159262NHLBI NIH HHS K23 HL169839NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL157635NHLBI NIH HHS T32 HL007208
6 · The paper itself

Abstract

backgroundAchievement of guideline-recommended levels of physical activity (≥150 minutes of moderate-to-vigorous physical activity per week) is associated with lower risk of adverse cardiovascular events and represents an important public health priority. Although physical activity commonly follows a "weekend warrior" pattern, in which most moderate-to-vigorous physical activity is concentrated in 1 or 2 days rather than spread more evenly across the week (regular), the effects of physical activity pattern across a range of incident diseases, including cardiometabolic conditions, are unknown.

methodsWe tested associations between physical activity pattern and incidence of 678 conditions in 89 573 participants (62±8 years of age; 56% women) of the UK Biobank prospective cohort study who wore an accelerometer for 1 week between June 2013 and December 2015. Models were adjusted for multiple baseline clinical factors, and

resultsWhen compared to inactive (<150 minutes moderate-to-vigorous physical activity/week), both weekend warrior (267 total associations; 264 [99%] with lower disease risk; hazard ratio [HR] range, 0.35-0.89) and regular activity (209 associations; 205 [98%] with lower disease risk; HR range, 0.41-0.88) were broadly associated with lower risk of incident disease. The strongest associations were observed for cardiometabolic conditions such as incident hypertension (weekend warrior: HR, 0.77 [95% CI, 0.73-0.80];

conclusionsAchievement of measured physical activity volumes consistent with guideline recommendations is associated with lower risk for >200 diseases, with prominent effects on cardiometabolic conditions. Associations appear similar whether physical activity follows a weekend warrior pattern or is spread more evenly throughout the week.

Indexed as

ExerciseAgedCardiovascular DiseasesFemaleHumansIncidenceMaleMiddle AgedProspective StudiesTime FactorsUnited Kingdomaccelerometrycardiovascular diseasephysical activitypreventionweekend warrior

Identifiers

PMID39324186
PMCPMC11803568

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.