ArticleFrontiers in oncology2024
Genomic alterations in the stepwise progression from normal mucosa to metastasizing oral squamous cell carcinoma.
Article in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Oral squamous cell carcinoma arising from oral epithelial dysplasia shows high postoperative recurrence despite favorable histopathology.Clinical oral investigations · 2026Article
- Comparative Analysis of the Tumour Mutational Burden in Erosive and Reticular Oral Lichen Planus.Oral diseases · 2025Article
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9 authors.
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Abstract
Introduction: The aim of this study was to investigate the genomic changes that occur in the development from dysplasia, cancer and to regional metastases in patients with oral cavity squamous cell carcinoma (OSCC). Material and methods: We included OSCC patients with lymph node metastases at diagnosis, treated with primary surgery at Rigshospitalet, University of Copenhagen in the period 2007-2014. The resected tumor specimens were evaluated by a pathologist, who marked areas of morphologically normal tissue and dysplasia surrounding the cancer, two areas from the cancer tissue, and one area within the lymph node metastases. From these areas a punch biopsy was taken, and DNA from each sample was extracted and sequenced using Illumina's TSO500 HT cancer panel. Results: From 51 OSCC patients, 255 samples were included, comprising a wide variety of genomic alterations. Substantial intratumor heterogeneity was found. The most commonly mutated gene was Conclusion: Substantial inter- and intratumor genomic heterogeneity was found. Mutation of
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