Evidence map›Paper›PMID 39323865›Full record

ArticleFrontiers in genetics2024

Ninein, a candidate gene for ethanol anxiolysis, shows complex exon-specific expression and alternative splicing differences between C57BL/6J and DBA/2J mice.

E R Gnatowski, J L Jurmain, M G Dozmorov, J T Wolstenholme, M F Miles

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Dysregulation of U12-Type Splicing in Lupus Neutrophils.Arthritis & rheumatology (Hoboken, N.J.) · 2026
    Article
  2. Dysregulation of U12-Type Splicing in Lupus Neutrophils.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E R GnatowskiDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, United States.
J L JurmainDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, United States.
M G DozmorovVCU Alcohol Research Center, Virginia Commonwealth University, Richmond, United States.
J T WolstenholmeDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, United States.
M F MilesDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, United States.

Funding

Project 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MICHAEL F MILES · 2014 to 2026
$19.6M
Gsk3b in ethanol consumption and as a therapeutic target for alcohol use disorderR01AA027581 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MILES, MICHAEL F · 2019 to 2023
$1.7M
The Role of Ninein in Ethanol AnxiolysisF31AA030727 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI GNATOWSKI, EMMA · 2022 to 2024
$125k
NIAAA NIH HHS F31 AA030727NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R01 AA027581
6 · The paper itself

Abstract

Ethanol's anxiolytic actions contribute to increased consumption and the development of Alcohol Use Disorder (AUD). Our laboratory previously identified genetic loci contributing to the anxiolytic-like properties of ethanol in BXD recombinant inbred mice, derived from C57BL/6J (B6) and DBA/2J (D2) progenitor strains. That work identified Ninein (

Indexed as

alternative splicinganxietyethanolexon skippingmouse geneticsNineinRNAseq

Identifiers

PMID39323865
PMCPMC11422218

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.