Predictive value of cuproptosis and disulfidptosis-related lncRNA in head and neck squamous cell carcinoma prognosis and treatment.

Objective: Head and neck squamous cell carcinoma (HNSCC) is a highly lethal and prevalent malignant tumor with a poor prognosis due to its high recurrence rate, This study aims to develop a prognostic index for HNSCC patients based on Cuproptosis and Disulfidptosis-related long noncoding RNA. Methods: Gene expression and clinical data for HNSCC were obtained from The Cancer Genome Atlas (TCGA). Using Lasso regression and multivariate Cox regression, we established a risk scoring model. The predictive ability of the nomogram, based on clinical features and risk scores, was verified using receiver operating characteristics and calibration curves. We compared independent prognostic parameters, risk score distribution, and survival between high-risk and low-risk groups, followed by preliminary validity evaluations of the model. Results: Our systematic evaluation of prognostic risk provides a new direction for improving the survival prognosis of HNSCC patients in clinical practice, The model effectively categorized patients into high- and low-risk groups with distinct outcomes, identifying numerous gene mutations in these groups, A low-risk score was associated with a better prognosis and higher survival rates. Conclusion: The risk score prognostic prediction system developed in this study shows potential efficacy in predicting the prognosis of HNSCC patients and has practical applications in clinical settings.