ArticleHeliyon2024
A computer approach to assess age-related changes of the brain white matter in Alzheimer's disease.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Design of a Nano-Functionalized Lab-on-Paper Optical Sensing Platform for On-Site Detection of Ascorbic Acid in Natural Fruit Juices.Applied biochemistry and biotechnology · 2025Article
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Background: Age is one of the major risk factors for Alzheimer's disease (AD) which is considered the most common adult-onset dementia. There is little information about age-related changes during brain dementia. Methods: This study observed age-related variations in the brain throughout adulthood in magnetic resonance imaging (MRI) of the AD and healthy brains. The Open Access Series of Imaging Studies (OASIS) is used as a database. The method consists of design and develop a computer approach based on artificial intelligence (AI) to segment white matter (WM) from the MRI. Then, the number of pixels within the segmented white matter (WM) of the brain was calculated. Correlation was used to investigate age relation with WM changes in the normal and AD brain. Results: The WM change with aging was more correlated in AD group (rAD = -0.505, p-value = 0.0007) than control group (rControl = -0.357, p-value = 0.0001). Conclusion: Higher correlation of WM pixel counts with age in AD group approved that AD is characterized by the relevant involvement of the WM and age. Our approach gained additional information on the quantitative pathological changes associated with the AD as the most common brain disorder of the elderly.
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Registered trials
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