Evidence map›Paper›PMID 39323765›Full record

ArticleBurns & trauma2024

Thermo-responsive cascade antimicrobial platform for precise biofilm removal and enhanced wound healing.

Ting Du, Jiangli Cao, Zhannuo Zhang, Zehui Xiao, Jingbo Jiao, Zhiyong Song, Xinjun Du, Shuo Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ting DuState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, No. 29, Thirteenth Street, Binhai New Area, Tianjin 300457, PR China.ORCID https://orcid.org/0000-0002-8980-9038
Jiangli CaoState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, No. 29, Thirteenth Street, Binhai New Area, Tianjin 300457, PR China.
Zhannuo ZhangState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, No. 29, Thirteenth Street, Binhai New Area, Tianjin 300457, PR China.
Zehui XiaoState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, No. 29, Thirteenth Street, Binhai New Area, Tianjin 300457, PR China.
Jingbo JiaoState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, No. 29, Thirteenth Street, Binhai New Area, Tianjin 300457, PR China.
Zhiyong SongCollege of Science, Huazhong Agricultural University, No. 1, Shizishan Street, Hongshan District, Wuhan 430070, PR China.
Xinjun DuState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, No. 29, Thirteenth Street, Binhai New Area, Tianjin 300457, PR China.
Shuo WangTianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, No. 38 Tongyan Road, Haihe Education Park, Jinnan District, Tianjin 300071, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bacterial infection, tissue hypoxia and inflammatory response can hinder infected wound repair. This study aimed to develop a multifunctional specific therapeutic photo-activated release nanosystem [HMPB@MB@AuNPs@PMB@HA (HMAPH)] by loading photosensitizer methylene blue (MB) into hollow mesoporous Prussian blue nanostructures and modifying the surface with gold particles, polymyxin B (PMB) and hydrophilic hyaluronic acid. Methods: The HMAPH was characterized using transmission electron microscopy, UV-vis, Fourier-transform infrared spectroscopy, X-ray diffraction and X-ray photon spectroscopy. The photothermal performance, iron ion release and free radical generation of the HMAPH were measured under different conditions to investigate its thermo-responsive cascade reaction. The antibacterial ability of HMAPH was investigated using live/dead fluorescence tests. The morphology and membrane integrity of Results: In this study, hyaluronic acid was decomposed under the action of hyaluronidase. Also, the exposed nanomaterials specifically bound to the outer membrane of Conclusions: Our study proposed a strategy against bacteria and biofilms through a synergistic photothermal-photodynamic-Fenton reaction, opening up new prospects for combating biofilm-associated infections.

Indexed as

BiofilmFenton reactionHMAPH nanocompositesInfectionPhotodynamicPhotothermalSynergistic antibacteriaWound healing

Identifiers

PMID39323765
PMCPMC11422504

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.