ArticleFrontiers in bioengineering and biotechnology2024
Case report: Improvement of gait with adaptive deep brain stimulation in a patient with Parkinson's disease.
Article in Frontiers in bioengineering and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Adaptive deep brain stimulation for dynamic gait control in Parkinson's disease: a randomized feasibility trial.Nature medicine · 2026Trial
- Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.Nature medicine · 2026Article
- Dopamine and the dynamics of subthalamic and leg muscle activities in parkinsonian stepping.Brain : a journal of neurology · 2026Article
- N2G calibrator: a cross-subject adversarial learning framework for neural signal-driven gait tracking in Parkinson's disease.Communications engineering · 2026Article
- Multitarget brain implants enable generalized decoding of Parkinson's disease symptoms from chronic home recordings.Research square · 2026Article
- Chronic adaptive deep brain stimulation in Parkinson's disease: ADAPT-START findings and programming principles.NPJ Parkinson's disease · 2026Article
- Advanced Therapeutics in Parkinson's Disease: What's New?Current neurology and neuroscience reports · 2026Review
- Low-Frequency Adaptive Deep Brain Stimulation for Parkinson's Disease.medRxiv : the preprint server for health sciences · 2025Article
- Adaptive deep brain stimulation timed to gait phase improves walking in Parkinson's disease.medRxiv : the preprint server for health sciences · 2025Article
- Online prediction of optimal deep brain stimulation contacts from local field potentials in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Transformer-based long-term predictor of subthalamic beta activity in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Subthalamic Activity Is Associated With Proactive Inhibition in Parkinson's Disease Patients.The European journal of neuroscience · 2025Article
- Beta burst-driven adaptive deep brain stimulation for gait impairment and freezing of gait in Parkinson's disease.Brain communications · 2025Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Gait disturbance is a common and severe symptom of Parkinson's disease that severely impairs quality of life. Current treatments provide only partial benefits with wide variability in outcomes. Also, deep brain stimulation of the subthalamic nucleus (STN-DBS), a mainstay treatment for bradykinetic-rigid symptoms and parkinsonian tremor, is poorly effective on gait. We applied a novel DBS paradigm, adjusting the current amplitude linearly with respect to subthalamic beta power (adaptive DBS), in one parkinsonian patient with gait impairment and chronically stimulated with conventional DBS. We studied the kinematics of gait and gait initiation (anticipatory postural adjustments) as well as subthalamic beta oscillations with both conventional and adaptive DBS. With adaptive DBS, the patient showed a consistent and long-lasting improvement in walking while retaining benefits on other disease-related symptoms. We suggest that adaptive DBS can benefit gait in Parkinson's disease possibly by avoiding overstimulation and dysfunctional entrainment of the supraspinal locomotor network.
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