Evidence map›Paper›PMID 39323483›Full record

ArticleFrontiers in microbiomes2023

Toll-like receptor 4 deletion partially protects mice from high fat diet-induced arterial stiffness despite perturbation to the gut microbiota.

Kayl E Ecton, Elliot L Graham, Briana D Risk, Gabriele D Brown, Grace C Stark, Yuren Wei, S Raj J Trikha, Tiffany L Weir, Christopher L Gentile

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiomes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kayl E EctonCell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO, United States.
Elliot L GrahamDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, United States.
Briana D RiskDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, United States.
Gabriele D BrownDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, United States.
Grace C StarkDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, United States.
Yuren WeiDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, United States.
S Raj J TrikhaDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, United States.
Tiffany L WeirCell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO, United States.
Christopher L GentileCell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO, United States.

Funding

The Obese Microbiota as a Novel Regulator of Vascular Function: A Translational ApproachR01HL144611 · NHLBI · COLORADO STATE UNIVERSITY · PI GENTILE, CHRISTOPHER L, WEIR, TIFFANY L · 2019 to 2022
$1.4M
NHLBI NIH HHS R01 HL144611
6 · The paper itself

Abstract

The present study aimed to determine the effects of toll-like receptor 4 (TLR4) deletion on high fat diet-induced aortic stiffness and gut microbiota alterations. We hypothesized that a high fat diet would result in perturbation of the gut microbiota in both control and TLR4 knockout mice (TLR4

Indexed as

arterial stiffnessgut microbiotalipopolysaccharides (LPS)pulse wave velocitytoll like receptor 4

Identifiers

PMID39323483
PMCPMC11423633

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.