Evidence map›Paper›PMID 39323479›Full record

ReviewToxicology research2024

A toxicogenomics-based identification of potential mechanisms and signaling pathways involved in PFCs-induced cancer in human.

Zahra Dehghani, Sara Ranjbar, Farbod Shahabinezhad, Pooria Sabouri, Afshin Mohammadi Bardbori

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Toxicology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zahra DehghaniDepartment of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Rokn Abad, Karafarin St., 7146864685, Shiraz, Iran.ORCID https://orcid.org/0000-0002-8833-662X
Sara RanjbarPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Rokn Abad, Karafarin St., 7146864685, Shiraz, Iran.ORCID https://orcid.org/0000-0002-7675-4146
Farbod ShahabinezhadDepartment of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Rokn Abad, Karafarin St., 7146864685, Shiraz, Iran.ORCID https://orcid.org/0000-0003-0489-6433
Pooria SabouriDepartment of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Rokn Abad, Karafarin St., 7146864685, Shiraz, Iran.ORCID https://orcid.org/0009-0007-8930-2708
Afshin Mohammadi BardboriDepartment of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Rokn Abad, Karafarin St., 7146864685, Shiraz, Iran.ORCID https://orcid.org/0000-0003-2203-6322

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The number of new diagnosed cancer cases and cancer deaths are increasing worldwide. Perfluorinated compounds (PFCs) are synthetic chemicals, which are possible inducers of cancer in human and laboratory animals. Studies showed that PFCs induce breast, prostate, kidney, liver and pancreas cancer by inducing genes being involved in carcinogenic pathways. Methodology: This study reviews the association between PFCs induced up-regulation/down-regulation of genes and signaling pathways that are important in promoting different types of cancer. To obtain chemical-gene interactions, an advanced search was performed in the Comparative Toxicogenomics Database platform. Results: Five most prevalent cancers were studied and the maps of their signaling pathways were drawn, and colored borders indicate significantly differentially expressed genes if there had been reports of alterations in expression in the presence of PFCs. Conclusion: In general, PFCs are capable of inducing cancer in human via altering PPARα and PI3K pathways, evading apoptosis, inducing sustained angiogenesis, alterations in proliferation and blocking differentiation. However, more epidemiological data and mechanistic studies are needed to better understand the carcinogenic effects of PFCs in human.

Indexed as

Breast cancerCancerColorectal cancerKidney cancerPerfluorinated compounds (PFCs)Prostate cancerSmall cell lung cancer

Identifiers

PMID39323479
PMCPMC11420517

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.