Evidence map›Paper›PMID 39323409›Full record

ArticleHaematologica2025

Acquired thrombotic thrombocytopenic purpura without detectable anti-ADAMTS13 antibodies: a possible underlying autoimmune mechanism.

Delphine Simon, Mathilde Leclercq, Bérangère Joly, Agnès Veyradier, Paul Coppo, Ygal Benhamou

Abstract readLetter
In one paragraph

Article in Haematologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Delphine SimonDépartement de Médecine interne, CHU Charles Nicolle, F-76000 Rouen.
Mathilde LeclercqDépartement de Médecine interne, CHU Charles Nicolle, F-76000 Rouen, France; Université de Rouen, INSERM U1234 PANTHER, F-76000 Rouen.
Bérangère JolyDépartement d'Hématologie biologique, Hôpital Lariboisière, AP-HP, F-75000, Paris, France; Equipe d'accueil 3518, Institut de Recherche Saint-Louis, Université de Paris, F-75000, Paris.
Agnès VeyradierDépartement d'Hématologie biologique, Hôpital Lariboisière, AP-HP, F-75000, Paris, France; Equipe d'accueil 3518, Institut de Recherche Saint-Louis, Université de Paris, F-75000, Paris.
Paul CoppoCentre de Référence des Microangiopathies Thrombotiques, Service d'Hématologie, APHP et Sorbonne Université, F-75000, Paris, France; INSERM Unité Mixte de Recherche (UMRS) 1138, Centre de Recherche des Cordeliers, F-75000, Paris.
Ygal BenhamouDépartement de Médecine interne, CHU Charles Nicolle, F-76000 Rouen, France; Université de Rouen, INSERM U1026 EnVI, F-76000 Rouen. ygal.benhamou@chu-rouen.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In up to 25% of patients with acquired TTP, anti-ADAMTS13 antibodies are not identified, the mechanism resulting from ADAMTS13 deficiency remains unidentified (uTTP). In this study, we provide further insights on clinical presentation and outcome of uTTP. In patients with baseline undetectable anti-ADAMTS13 antibodies, usual features of iTTP (young age, cerebral involvement, severe thrombocytopenia) with no other associated context than a history of systemic autoimmune disease or pregnancy, should prompt to consider the diagnosis of iTTP.

Indexed as

ADAMTS13 ProteinAutoantibodiesPurpura, Thrombotic ThrombocytopenicAdultFemaleHumansMaleMiddle AgedADAMTS13 ProteinADAMTS13 protein, humanAutoantibodies

Identifiers

PMID39323409
PMCPMC12130786

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.