Evidence map›Paper›PMID 39323387›Full record

ArticleAmerican journal of physiology. Renal physiology2024

Acute kidney injury results in long-term alterations of kidney lymphatics in mice.

Gelare Ghajar-Rahimi, Daria Barwinska, Grace E Whipple, Malgorzata M Kamocka, Shehnaz Khan, Seth Winfree, Jennifer Lafontaine, Reham H Soliman, Arin L Melkonian, Anna A Zmijewska and 10 more

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Normal cardiac lymphatics and their mimics.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Gelare Ghajar-RahimiDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0001-5089-7176
Daria BarwinskaDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States.ORCID 0000-0002-0776-3030
Grace E WhippleDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Malgorzata M KamockaDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Shehnaz KhanDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Seth WinfreeDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States.ORCID 0000-0002-2396-5871
Jennifer LafontaineBirmingham Veterans Administration Medical Center, Birmingham, Alabama, United States.
Reham H SolimanDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Arin L MelkonianDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-1842-1343
Anna A ZmijewskaDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Matthew D CheungDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0003-4182-5220
Amie M TraylorDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Yanlin JiangDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0003-1235-2671
Zhengqin YangDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Subhashini BolisettyDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-4650-3151
Abolfazl ZarjouDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-8676-847X
Timmy LeeDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-5305-7268
James F GeorgeDivision of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0003-0325-7891
Tarek M El-AchkarDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States.ORCID 0000-0003-4645-3614
Anupam AgarwalDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0003-4276-5186

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8M
Resource Development CoreU54DK137328 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Pierre C Dagher · 2023 to 2026
$4.5M
UAB-UCSD O'Brien Center for Acute Kidney Injury ResearchU54DK137307 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PAUL W. SANDERS · 2023 to 2026
$4.4M
Deep South KUH Premier Research - Interdisciplinary Mentored Education (PRIME) Training CoreTL1DK139566 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVID M POLLOCK · 2023 to 2026
$3.6M
Deep South KUH Premier Research- Interdisciplinary Mentored Education (PRIME) Networking CoreU2CDK133422 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kelly Hyndman · 2023 to 2026
$2.8M
Mononuclear phagocytes in the pathogenesis of acute kidney injuryR01DK118932 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM, GEORGE, JAMES F · 2019 to 2023
$2.3M
Functional Significance of Ferritin Light Chain in Sepsis-associated Kidney InjuryR01DK122986 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOLISETTY, SUBHASHINI · 2021 to 2025
$1.7M
Regulation of Macrophage Phenotype by Ferritin Heavy Chain in CKDR01DK134402 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Abolfazl Zarjou · 2023 to 2026
$1.6M
UAB KUH KURER25DK115353 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jennifer S Pollock · 2018 to 2026
$1.0M
PRedoctoral Interdisciplinary training in renal physiology and MEdicine (PRIME)T32DK116672 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POLLOCK, JENNIFER S · 2018 to 2022
$761k
American Heart Association (AHA) 23PRE1026852BLRD VA I01 BX003935BLRD VA I01 BX004047HHS | NIH | National Cancer Institute (NCI) CA013148HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK137307HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) PRIME T32 DK 116672HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32-GM-008361HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) AI027767HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) 1F30DK135349-01A1HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK118932HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK122986NCI NIH HHS P30 CA013148NIAID NIH HHS P30 AI027767NIDDK NIH HHS F30 DK135349NIDDK NIH HHS R01 DK118932NIDDK NIH HHS R01 DK122986NIDDK NIH HHS R01 DK134402NIDDK NIH HHS R25 DK115353NIDDK NIH HHS T32 DK116672NIDDK NIH HHS TL1 DK139566NIDDK NIH HHS U2C DK133422NIDDK NIH HHS U54 DK137307NIDDK NIH HHS U54 DK137328NIGMS NIH HHS T32 GM008361U.S. Department of Veterans Affairs (VA) 5I01BX004047-34003797
6 · The paper itself

Abstract

The long-term effects of a single episode of acute kidney injury (AKI) induced by bilateral ischemia-reperfusion injury (BIRI) on kidney lymphatic dynamics are not known. The purpose of this study was to determine if alterations in kidney lymphatics are sustained in the long term and how they relate to inflammation and injury. Mice underwent BIRI as a model of AKI and were followed up to 9 mo. Although kidney function markers normalized following initial injury, histological analysis revealed sustained tissue damage and inflammation for up to 9 mo. Transcriptional analysis showed both acute and late-stage lymphangiogenesis, supported by increased expression of lymphatic markers, with unique signatures at each phase. Expression of

Indexed as

Acute Kidney InjuryDisease Models, AnimalKidneyLymphangiogenesisLymphatic VesselsMice, Inbred C57BLReperfusion InjuryAnimalsChemokine CCL21MaleMiceTertiary Lymphoid StructuresTime FactorsChemokine CCL21acute kidney injuryCcl21alymphangiogenesislymphaticstertiary lymphoid tissue

Identifiers

PMID39323387
PMCPMC11563594

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.