Evidence map›Paper›PMID 39323031›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Comprehensive Analysis Identifies Hyaluronan Mediated Motility Receptor and Cell Division Cycle 25C as Potential Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma.

Hongrui Zhang, Yi Xu, Haijun Han, Xiongwei Ye, Lu Cheng, Yueshuang Shen, Xiaochen Wan

Abstract read
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hongrui ZhangDepartment of Clinical Laboratory, Zhejiang Hospital, Hangzhou, China.
Yi XuDepartment of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Haijun HanSchool of Medicine, Hangzhou City University, Hangzhou, China.
Xiongwei YeDepartment of Clinical Laboratory, Zhejiang Hospital, Hangzhou, China.
Lu ChengDepartment of Clinical Laboratory, Zhejiang Hospital, Hangzhou, China.
Yueshuang ShenDepartment of Clinical Laboratory, Zhejiang Hospital, Hangzhou, China.
Xiaochen WanDepartment of Clinical Laboratory, Zhejiang Hospital, Hangzhou, China.ORCID 0009-0002-1517-1569

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHead and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, but its pathogenic mechanisms remain unclear. This study aimed to identify the potential biomarkers underlying the diagnosis and treatment of HNSCC.

methodsWeighted gene co-expression network analysis (WGCNA) followed by pathway enrichment analysis, analysis of infiltrating immune cells, survival analysis, and methylation analysis were applied to identify the potential hub genes underlying the prognosis of HNSCC. The expression of hub genes was validated by immunofluorescence staining.

resultsA total of 10,274 differentially expressed genes (DEGs) were identified. Through WGCNA, the yellow module (

conclusionTwo real hub genes (

Indexed as

Biomarkers, TumorHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckCell Cycle ProteinsExtracellular Matrix ProteinsGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansHyaluronan ReceptorsMalePrognosisSurvival AnalysisBiomarkers, TumorCell Cycle ProteinsExtracellular Matrix Proteinshyaluronan-mediated motility receptorHyaluronan Receptorscell cycleHNSCCimmune infiltrationsurvivalTCGAWGCNA

Identifiers

PMID39323031
PMCPMC11440566

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.