Evidence map›Paper›PMID 39322980›Full record

ArticleAnnals of medicine2024

Clinicopathological analysis of nasopharyngeal tuberculosis.

Il Gyu Kong, Jiwon Koh, Sue Jean Mun, Nakwon Kwak, Doo Hee Han

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Article in Annals of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Il Gyu KongDepartment of Otorhinolaryngology-Head and Neck Surgery, Hospital Medicine Center, Seoul National University Hospital, Seoul, South Korea.ORCID 0000-0001-8430-9862
Jiwon KohDepartment of Pathology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.ORCID 0000-0002-7687-6477
Sue Jean MunDepartment of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine, Pusan, South Korea.ORCID 0000-0003-4486-7178
Nakwon KwakDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.ORCID 0000-0002-1897-946X
Doo Hee HanDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.ORCID 0000-0003-3367-1495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study is to examine the clinical and pathological attributes of nasopharyngeal tuberculosis.

methodsWe conducted a retrospective analysis of the clinicopathologic characteristics of nasopharyngeal tuberculosis in 14 patients. The medical records and imaging data obtained between March 2004 and February 2023 were scrutinized. During the pathological review, we classified the types of granulomatous inflammation and graded the extent of caseation.

resultsResults indicate a 100% female predominance, with chief complaints including hearing loss, postnasal drip, and nasal obstruction. Cervical lymphadenopathy occurred in 21.4% of patients. Chest radiograph abnormalities were found in 58.3%, with three showing active pulmonary tuberculosis. Endoscopic examination revealed three types of lesions, and CT/MRI findings correlated with gross lesions. A statistically significant association was found between lesion characteristics (bulging, ulcerative, necrotic) and pathology patterns (sarcoidosis-like, caseation). Bulging masses exhibited sarcoidosis-like patterns, while ulcerative/necrotic lesions were often associated with caseation. All lesions responded well to over six months of anti-tuberculosis medication, leading to favourable outcomes.

conclusionWe studied 14 cases of nasopharyngeal tuberculosis, mostly in females, with common ear and nose symptoms. Lesions were typically visible on nasopharyngeal endoscopy, and endoscopically bulging mass-like lesions had pathologically sarcoidosis-like granulomas. All patients had favourable outcomes.

Indexed as

Nasopharyngeal DiseasesAdolescentAdultAgedAntitubercular AgentsEndoscopyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNasopharynxRetrospective StudiesTomography, X-Ray ComputedTuberculosisYoung AdultAntitubercular AgentsendoscopygranulomaNasopharynxtuberculosis

Identifiers

PMID39322980
PMCPMC11425682

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.