Evidence map›Paper›PMID 39322758›Full record

ArticleThe EMBO journal2024

Toxin-mediated depletion of NAD and NADP drives persister formation in a human pathogen.

Isabella Santi, Raphael Dias Teixeira, Pablo Manfredi, Hector Hernandez Gonzalez, Daniel C Spiess, Guillaume Mas, Alexander Klotz, Andreas Kaczmarczyk, Simon van Vliet, Nicola Zamboni and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Isabella Santi *Biozentrum, University of Basel, Basel, Switzerland.
Raphael Dias Teixeira *Biozentrum, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0001-9642-7508
Pablo ManfrediBiozentrum, University of Basel, Basel, Switzerland.
Hector Hernandez GonzalezBiozentrum, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0009-0006-8591-8479
Daniel C SpiessBiozentrum, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0009-0003-3113-8176
Guillaume MasBiozentrum, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-2351-0455
Alexander KlotzBiozentrum, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-4666-8607
Andreas KaczmarczykBiozentrum, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-6616-1777
Simon van VlietBiozentrum, University of Basel, Basel, Switzerland.
Nicola ZamboniInstitute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0003-1271-1021
Sebastian HillerBiozentrum, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-6709-4684
Urs JenalBiozentrum, University of Basel, Basel, Switzerland. urs.jenal@unibas.ch.ORCID http://orcid.org/0000-0002-1637-3376

Funding

National Center of Competence in Research AntiResist (NCCR AntiResist) 51NF40_180541Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 310030_189253
6 · The paper itself

Abstract

Toxin-antitoxin (TA) systems are widespread in bacteria and implicated in genome stability, virulence, phage defense, and persistence. TA systems have diverse activities and cellular targets, but their physiological roles and regulatory mechanisms are often unclear. Here, we show that the NatR-NatT TA system, which is part of the core genome of the human pathogen Pseudomonas aeruginosa, generates drug-tolerant persisters by specifically depleting nicotinamide dinucleotides. While actively growing P. aeruginosa cells compensate for NatT-mediated NAD

Indexed as

NADNADPPseudomonas aeruginosaToxin-Antitoxin SystemsBacterial ProteinsBacterial ToxinsHumansPseudomonas InfectionsVirulenceBacterial ProteinsBacterial ToxinsNADNADPNADasePersistersPseudomonas aeruginosaRES DomainToxin–antitoxin System

Identifiers

PMID39322758
PMCPMC11535050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.