Evidence map›Paper›PMID 39322740›Full record

ArticleEMBO reports2024

Kinesin-1 mediates proper ER folding of the Ca

Yosuke Tanaka, Atena Farkhondeh, Wenxing Yang, Hitoshi Ueno, Mitsuhiko Noda, Nobutaka Hirokawa

Abstract read
In one paragraph

Article in EMBO reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Roles of molecular motors in insulin-secreting beta cells.Current opinion in cell biology · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yosuke TanakaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, 113-0033, Japan.ORCID 0000-0001-5376-5726
Atena FarkhondehDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, 113-0033, Japan.ORCID 0000-0003-4595-1435
Wenxing YangDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, 113-0033, Japan.
Hitoshi UenoDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, 113-0033, Japan.
Mitsuhiko NodaDepartment of Diabetes, Metabolism and Endocrinology, Ichikawa Hospital, International University of Health and Welfare, Chiba, 272-0827, Japan.
Nobutaka HirokawaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, 113-0033, Japan. hirokawa@m.u-tokyo.ac.jp.ORCID 0000-0002-0081-5264

Funding

Japan IDDM network N.A.JEOL, Ltd. N.A.MEXT | Japan Society for the Promotion of Science (JSPS) JP20K06634MEXT | Japan Society for the Promotion of Science (JSPS) JP23000013 and JP16H06372Ono Medical Research Foundation N.A.Uehara Memorial Foundation (UMF) N.A.
6 · The paper itself

Abstract

Glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells is a principal mechanism for systemic glucose homeostasis, of which regulatory mechanisms are still unclear. Here we show that kinesin molecular motor KIF5B is essential for GSIS through maintaining the voltage-gated calcium channel Ca

Indexed as

Calcium Channels, L-TypeEndoplasmic ReticulumGlucoseHomeostasisHSP90 Heat-Shock ProteinsInsulinInsulin-Secreting CellsInsulin SecretionKinesinsMice, KnockoutProtein FoldingAnimalsCalciumHSP70 Heat-Shock ProteinsMiceCACNA1C protein, mouseCalciumCalcium Channels, L-TypeGlucoseHSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsInsulinKif5b protein, mouseKinesinsCalcium ChannelER SheetsHsp90Insulin SecretionKinesin

Identifiers

PMID39322740
PMCPMC11549326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.