Evidence map›Paper›PMID 39322590›Full record

ArticleBMJ open2024

Atrial fibrillation after cardiac surgery: identifying candidate predictors through a Delphi process.

Jonathan Bedford, Kara G Fields, Gary Stephen Collins, Gregory Y H Lip, David A Clifton, Benjamin O'Brien, Jochen D Muehlschlegel, Peter J Watkinson, Oliver C Redfern

Registry-linked trialAbstract read
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05255224 (Predicting AF After Cardiac Surgery - the PARADISE Score. A Clinical Prediction Rule for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05255224 unknown statusnot on this map

Predicting AF After Cardiac Surgery - the PARADISE Score. A Clinical Prediction Rule for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

TypeobservationalSponsorUniversity of OxfordRan2021 to 2025Enrolled13,684ConditionsAtrial Fibrillation New OnsetArmsNot applicable as observational study
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonathan BedfordNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK Jonathan.Bedford@ndcn.ox.ac.uk.ORCID 0000-0001-9455-022X
Kara G FieldsDepartment of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Gary Stephen CollinsCentre for Statistics in Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-2772-2316
Gregory Y H LipLiverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, Merseyside, UK.ORCID 0000-0002-7566-1626
David A CliftonDepartment of Engineering Science, University of Oxford, Oxford, UK.
Benjamin O'BrienDepartment of Cardiac Anesthesiology and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
Jochen D MuehlschlegelDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, UK.
Peter J WatkinsonNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0003-1023-3927
Oliver C RedfernNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Funding

Genomics of Post-Operative Atrial Fibrillation After Cardiac SurgeryR01HL149998 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MUEHLSCHLEGEL, JOCHEN DANIEL, STRANGER, BARBARA E · 2021 to 2024
$3.1M
NHLBI NIH HHS R01 HL149998
6 · The paper itself

Abstract

objectivesThis study was undertaken to identify potential predictors of atrial fibrillation after cardiac surgery (AFACS) through a modified Delphi process and expert consensus. These will supplement predictors identified through a systematic review and cohort study to inform the development of two AFACS prediction models as part of the PARADISE project (NCT05255224). Atrial fibrillation is a common complication after cardiac surgery. It is associated with worse postoperative outcomes. Reliable prediction of AFACS would enable risk stratification and targeted prevention. Systematic identification of candidate predictors is important to improve validity of AFACS prediction tools.

designThis study is a Delphi consensus exercise.

settingThis study was undertaken through remote participation.

participantsThe participants are an international multidisciplinary panel of experts selected through national research networks.

interventionsThis is a two-stage consensus exercise consisting of generating a long list of variables, followed by refinement by voting and retaining variables selected by at least 40% of panel members.

resultsThe panel comprised 15 experts who participated in both stages, comprising cardiac intensive care physicians (n=3), cardiac anaesthetists (n=2), cardiac surgeons (n=1), cardiologists (n=4), cardiac pharmacists (n=1), critical care nurses (n=1), cardiac nurses (n=1) and patient representatives (n=2). Our Delphi process highlighted candidate AFACS predictors, including both patient factors and those related to the surgical intervention. We generated a final list of 72 candidate predictors. The final list comprised 3 demographic, 29 comorbidity, 4 vital sign, 13 intraoperative, 10 postoperative investigation and 13 postoperative intervention predictors.

conclusionsA Delphi consensus exercise has the potential to highlight predictors beyond the scope of existing literature. This method proved effective in identifying a range of candidate AFACS predictors. Our findings will inform the development of future AFACS prediction tools as part of the larger PARADISE project. TRIAL REGISTRATION NUMBER: NCT05255224.

Indexed as

Atrial FibrillationCardiac Surgical ProceduresConsensusDelphi TechniquePostoperative ComplicationsHumansRisk AssessmentRisk Factorscardiac surgerypacing & electrophysiologyrisk factors

Identifiers

PMID39322590
PMCPMC11425939

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.