SynthesisInternational dental journal2025
Oral Candida-biome and Early Childhood Caries: A Systematic Review and Meta-Analysis.
Synthesis in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed.
- Metagenomics as an Effective Diagnostic Approach for Exploring Oral Microbial Diversity and Dental Diseases: A Narrative Review.International journal of clinical pediatric dentistry · 2026Review
- Artemisinins inhibited the synergistic cariogenic effect betweenFrontiers in cellular and infection microbiology · 2026Article
- The pediatric oral mycobiome: a comprehensive review of its role in health and disease.Frontiers in cellular and infection microbiology · 2026Review
- Article
- The Impact of Bacterial-Fungal Interactions on Childhood Caries Pathogenesis.Pathogens (Basel, Switzerland) · 2025Article
- Probiotics, Prebiotics, Synbiotics, and Postbiotics Against Oral Candida in Children: A Review of Clinical Trials.Nutrients · 2025Review
- Multifaceted roles ofFrontiers in cellular and infection microbiology · 2025Review
- Article
- Understanding dental pulp inflammation: from signaling to structure.Frontiers in immunology · 2024Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCandida is a common fungal pathogen in the oral cavity, with Candida albicans being the most prevalent species. Some studies report a correlation between Candida prevalence and dental caries experience in preschoolers, while others report no such association. This systematic review and meta-analysis aimed to evaluate the association of Candida-biome with Early Childhood Caries (ECC) in preschool children.
methodsSeven databases were searched for studies evaluating the correlation between Candida and ECC in healthy preschool children under 71 months of age. Dual independent screening, data extraction, bias risk assessment, meta-analysis, and quality evaluation of evidence were conducted.
resultsThe review included 20 studies with 12 reporting a positive association between Candida prevalence and ECC. The prevalence of Candida albicans in ECC ranged from 60%-84% across sample sites. Certain specific species, including C. dubliniensis and atypical non-albicans Candida (NAC), were also associated with caries severity in preschoolers. The pooled odds ratio (OR) estimate was 7.98 (95%CI; 3.84-16.58) for Candida-biome in plaque samples (I² = 84%), and 9.42 (95%CI: 4.15- 21.40) for Candida-biome in saliva sample (I² = 50%). These results suggest that children with Candida-biome in plaque and saliva have higher odds of having ECC than caries-free children.
conclusionsChildren with Candida-biome in plaque and saliva samples have a higher risk of Early Childhood Caries, predominantly associated with Candida albicans. Standardised methodologies for evaluating and comparing data on Candida species and ECC are recommended for future studies.
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